This episode is with Charles Brenner. He is the Alfred E Mann Family  Foundation Chair in the department of Diabetes and Cancer Metabolism.  His research focuses on disturbances in nicotinamide adenine  dinucleotide (NAD), the central catalyst of metabolism, in diseases and  conditions of metabolic stress.  

Here we talk about what is metabolism?, NAD system, factors affecting  NAD system, ageing, anti-ageing research and how NAD system can be used  in health?  

Guest info: 

Website: https://www.brennerlab.net/ 

Twitter: https://twitter.com/CharlesMBrenner?s=20&t=sP8HvddsdScE8qzeQN_t3Q 

Google scholar: https://scholar.google.com/citations?user=XgEjtucAAAAJ&hl=en  

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Timestamps: 

00:00:00 Introduction 

00:00:51 What is metabolism? 

00:01:40 Metabolism at cellular level 

00:02:44 Different metabolic processes  

00:04:50 NAD (Nicotinamide adenine diamide) system  

00:08:20 Food to NAD system   

00:13:09 Evolutionary history of NAD system   

00:15:44 Molecular description of NAD system  

00:20:51 Synthesis of NAD  

00:23:21 What is metabolic stress?  

00:28:23 Consequences of metabolic stress on NAD system  

00:29:45 Conditions caused by NAD deficiency  

00:34:23 Impact of food on metabolic stress  

00:35:51 Different types of foods and NAD levels  

00:40:01 NAD levels and circadian rythem  

00:40:50 Genetic predisposition to NAD levels 

00:42:40 Are there population wide changes in NAD systems?  

00:47:25 Importance of NAD levels in the blood and how much of these can enter in the cell?  

00:50:08 Are there modified NMN compounds which can enter in the cell?  

00:52:01 NAD system and aging  

01:02:25 Objection against 'Sirtuins as drivers of aging' 

01:04:29 How do we understand aging? 

01:08:25 Biochemical explanation of aging  

01:12:20 What kind of biomarkers can help is in studying aging?  

01:15:33 Charles' work on NAD system  

01:17:05 What sort of system can help us study aging?  

01:23:37 Lifestyle and NAD system   

01:26:07 NR (Nicotinamide Ribose) as supplements  

01:27:19 Thank you!    

#reasonwithscience #health #aging