The US is a global leader in introducing new medical products, but the ability to generate evidence to inform clinical practice in postmarket settings must improve. Insurers may have an important role to play. Robert M. Califf, MD, of the US Food and Drug Administration, discusses why and how payers could support evidence generation with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Why Evidence Generation Should Matter to Payers and How They Can Help

What are the common signs and symptoms of celiac disease and how is this disease diagnosed and managed? Author Kerstin Austin, MD, from the University of Wisconsin-Madison, discusses this and more with JAMA Associate Editor David L. Simel, MD, MHS. Related Content: Diagnosis and Management of Celiac Disease

Hospitals are on the frontlines of the US gun violence epidemic, both through the treatment of shooting victims and as sites of firearm violence. At least 240 shootings occurred on US hospital grounds from 2000 to 2016 alone. Author Joseph Blocher, MPhil, JD, from Duke Law School talks about this and more with JAMA Network Open Editor in Chief Frederick P. Rivara, MD, MPH. Related Content: Firearm Policy in the Hospital Setting—Recognizing Health Care as a “Sensitive Place” State Approaches to Stopping Violence Against Health Care Workers

Interview with John M. Ruiz, PhD, USPSTF member and coauthor of Management of BMI in Children: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Interventions for Weight Management in Children and Adolescents Interventions for High Body Mass Index in Children and Adolescents Interventions for High BMI in Children and Teenagers Treatment Interventions for Child and Adolescent Obesity

Expert in critical care medicine, Romain Pirracchio, discusses the benefits of using low-dose corticosteroids in treating severe pulmonary infections. Topics include the use of corticosteroids in COVID-19 cases, positive impacts on mortality in Community-Acquired Pneumonia, and guidelines for timely initiation of treatment in critically ill patients.

Approximately 9% of US adults experience major depression each year, with lifetime prevalence nearly 17% for men and 30% for women. Effective first-line depression treatments include forms of psychotherapy and medication. Close monitoring significantly improves likelihood of treatment success. Gregory E. Simon, MD, MPH, discusses depression treatment with JAMA Senior Editor Karen E. Lasser, MD, MPH. Related Content: Management of Depression in Adults

Homelessness is detrimental to health and clinicians can play an important role in mitigating the deleterious effects of homelessness. Margot Kushel, MD, University of California, San Francisco, discusses this and more with JAMA Senior Editor Karen E. Lasser, MD, MPH. Related Content: Health Care for People Experiencing Homelessness

Interview with Li Li, MD, PhD, MPH, USPSTF member and coauthor of Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Interventions to Prevent Falls in Community-Dwelling Older Adults Interventions to Prevent Falls in Older Adults Preventing Falls in Older Persons Prevention of Falls in Older Adults

Respiratory syncytial virus (RSV) is a common infection that may cause severe illness in infants, young children, and older adults. Kathleen A. Linder, MD, of the VA Ann Arbor Healthcare System, discusses therapies to prevent severe RSV illness with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Therapies to Decrease Severe Respiratory Syncytial Virus Illness Assessing the Real-World Effectiveness of Immunizations for Respiratory Syncytial Virus

Chronic pruritus, defined as itch lasting more than 6 weeks, affects approximately 22% of people in their lifetime. In this JAMA clinical review podcast, dermatologist Daniel C. Butler, MD, from the University of Arizona College of Medicine, joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss evaluation and management of chronic pruritus. Related Content: Chronic Pruritus