Effectiveness of Anti-Obesity Medications

Three FDA-approved anti-obesity medications—liraglutide, semaglutide, and terzepatide—are effective in addressing obesity, affecting approximately 19% of women and 14% of men globally. Semaglutide, for instance, can result in an average weight loss of about 15%, while terzepatide may achieve 20% weight loss compared to placebo. While these medications mitigate appetite dysregulation, side effects primarily involve gastrointestinal issues, which can be managed through gradual dosage increases and dietary modifications. Counseling on a healthy diet, such as choosing smaller meals and reducing fat intake, further minimizes these side effects and supports successful weight management efforts.