Read the full transcript here. What are focused research organizations? Which kinds of research projects lend themselves to the FRO model? Researchers in academia frequently complain about the incentive structures around funding and publishing; so how do FROs change those dynamics? Why must FROs be time-limited, especially if they're successful? Who's in charge in an FRO? How does "field-building" help to improve science? What effects might large language models have on science?Adam Marblestone is the CEO of Convergent Research. He's been launching Focused Research Organizations (FROs) such as E11 bio and Cultivarium. He also serves on the boards of several non-profits pursuing new methods of funding and organizing scientific research including Norn Group and New Science. Previously, he was a Schmidt Futures Innovation Fellow, a consultant for the Astera Institute, a Fellow with the Federation of American Scientists (FAS), a research scientist at Google DeepMind, Chief Strategy Officer of the brain-computer interface company Kernel, a research scientist at MIT, a PhD student in biophysics with George Church and colleagues at Harvard, and a theoretical physics student at Yale. He also previously helped to start companies like BioBright and advised foundations such as the Open Philanthropy Project. His work has been recognized with a Technology Review 35 Innovators Under 35 Award (2018), a Fannie and John Hertz Foundation Fellowship (2010), and a Goldwater Scholarship (2008). Learn more about him at adammarblestone.org. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. How does the world differ from our perception of it? Where is color located? Is the self constructed in the same way our concept of the world is constructed? Aside from being interesting bits of trivia, why does any of that really matter? In what ways does perception most often differ among humans? How different are art and science?Anil Seth is a neuroscientist, author, and public speaker who has pioneered research into the brain basis of consciousness for more than twenty years. His mission is to advance the science of consciousness, and to use its insights for the benefits of society, technology, and medicine. He is Professor of Cognitive and Computational Neuroscience at the University of Sussex; Co-Director of the Canadian Institute for Advanced Research Program on Brain, Mind, and Consciousness; a European Research Council Advanced Investigator; and Editor-in-Chief of the academic journal Neuroscience of Consciousness. He has published more than 180 research papers and has been recognized by Web of Science, over several years, as being in the top 0.1% of researchers worldwide. A former Wellcome Trust Engagement Fellow, his two TED talks have been viewed more than thirteen million times, he has appeared in several films, and he has written for Aeon, The Guardian, Granta, New Scientist, and Scientific American, and he is lead scientist on the Dreamachine project. His new book Being You: A New Science of Consciousness was an instant Sunday Times Bestseller and a 2021 Book of the Year for The Economist, The New Statesman, Bloomberg Business, The Guardian, The Financial Times and elsewhere. Check out Dreamachine, take part in The Perception Census, visit Anil's website, or follow him on Twitter, Instagram, Facebook, or LinkedIn. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. What is the capabilities approach to welfare? To what is this approach reacting? How should capabilities be balanced or traded off against each other? How do capabilities differ from needs? Are zoos unethical? Can plants be subject to injustice? What are our ethical obligations towards factory farms? How do our ethical obligations to domesticated animals and livestock differ from our ethical obligations to wild animals, if at all? Why is vulnerability important? Is inequality intrinsically bad, or is it only bad because of its effects?Martha C. Nussbaum is the Ernst Freund Distinguished Service Professor of Law and Ethics, appointed in the Philosophy Department and the Law School of the University of Chicago. She gave the 2016 Jefferson Lecture for the National Endowment for the Humanities and won the 2016 Kyoto Prize in Arts and Philosophy, the 2018 Berggruen Prize in Philosophy and Culture, and the 2020 Holberg Prize. These three prizes are regarded as the most prestigious awards available in fields not eligible for a Nobel. She has written more than twenty-two books, including Upheavals of Thought: The Intelligence of Emotions; Anger and Forgiveness: Resentment, Generosity, Justice; Not for Profit: Why Democracy Needs the Humanities; The Monarchy of Fear, and most recently Justice for Animals: Our Collective Responsibility. Learn more about her via her University of Chicago bio. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. What is charity entrepreneurship? What sorts of incentives pull charities away from their stated goals? Why is Effective Altruism even a thing when it's already the case that most charities probably try to be as effective as they can be and probably use evidence of some kind to move towards that end? How diverse are the value systems in the EA movement? To what extent should charity funders diversify? Under what conditions does expected value theory break down? Is it possible to be too altruistic? Have too many EA orgs moved away from more traditional, near-term causes to pursue long-term causes? How frequently should charities switch projects? What is foundation entrepreneurship? What's the best advice to give to a non-EA person who wants to do some amount of good in the world?Joey Savoie wants to make the biggest positive difference in the world that he can. His mission is to cause more effective charities to exist in the world by connecting talented individuals with high-impact intervention opportunities. To achieve this, he co-founded Charity Entrepreneurship, an organization that launches effective charities through an extensive research process and incubation program. Prior to Charity Entrepreneurship, he co-founded Charity Science, a meta-organization that increased the amount of counterfactual funding going to high-impact charities. Subsequently, he co-founded Charity Science Health, a nonprofit that increases vaccination rates in India using mobile phones and behavioral nudges. He has given lectures on various aspects of charity entrepreneurship and Effective Altruism in Oxford, Cambridge, Harvard, Yale, EAG London, EAG San Francisco, Berlin, Basel, Vancouver, Stockholm, and Oslo. Learn more about Charity Entrepreneurship here, and learn more about Joey here. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. Are the US's culture wars a sign of a society falling apart? Is social media a cause or a symptom (or both or neither) of the animosity between political tribes in the US? We've all heard of postmodernism, but what the heck is it? Is libertarianism a right-leaning ideology? Are the current levels of intergenerational animosity unusually high? How will the FTX collapse likely impact cryptocurrencies over the next few decades?Nick Gillespie is an editor at large at Reason, the libertarian magazine of "free minds and free markets", and host of The Reason Interview with Nick Gillespie. Gillespie served as the editor in chief for Reason.com and Reason TV from 2008 through 2017 and was Reason magazine's editor in chief from 2000 to 2008. Under his direction, Reason won the 2005 Western Publications Association "Maggie" Award for Best Political Magazine. His work has appeared in The New York Times, The Washington Post, The Wall Street Journal, The Los Angeles Times, The New York Post, Slate, Salon, Time.com, Marketplace, and numerous other publications; and he is a frequent commentator on radio and television networks such as National Public Radio, CNBC, CNN, C-SPAN, Fox Business, Fox News Channel, MSNBC, and PBS. He holds a Ph.D. in English literature from the State University of New York at Buffalo. He also holds an M.A. in English with a concentration in creative writing from Temple University and a B.A. in English and Psychology from Rutgers University. Follow him on Twitter at @nickgillespie. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. What are "variance-amplifying" and "variance-dampening" institutions? Has the world been getting weirder recently? Should entrepreneurs aim for variance amplification or variance dampening? What percentage of people should be entrepreneurs? What traits and skills are necessary for successful entrepreneurship? How has ambition changed over the course of history? How can entrepreneurs know if they're really changing the world, or just doing something slightly before someone else did it, or just doing something that would have happened anyway? How can entrepreneurs avoid getting mired in "tar pit" ideas?Matt Clifford MBE is cofounder and CEO of Entrepreneur First, the leading technology company builder that invests in top technical individuals to help them build world-class deep technology startups from scratch in six locations across Europe, Asia, and Canada. Since 2011, Entrepreneur First has created over 500 startups worth over $10bn including Magic Pony Technology, Tractable, and CloudNC. Matt is also Chairman of the UK's new Advanced Research and Invention Agency (ARIA), which aims to enable exceptional scientists and researchers to identify and fund transformational research that leads to new technologies, discoveries, products, and services. Matt sits on the board of Code First Girls, which he co-founded in 2013 to teach young women how to code, and is a member of the Innovate UK Council. Matt started his career at McKinsey & Co. and holds degrees from Cambridge and MIT, where he was a Kennedy Scholar. He was awarded an MBE for services to business in the 2016 Queen's Birthday Honours. Follow him on Twitter, interact with him on LinkedIn, or learn more about his work at Entrepreneur First. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. What would happen if you chose to let ChatGPT control your life for a year? If products like ChatGPT help us (e.g.) to write something important, then should we give it credit as a co-author or merely act as though it's a high-powered Grammarly? How would you feel if you received a hand-written card from a romantic partner but later found out that everything they'd written had been authored by ChatGPT? How can we learn to get along with — and perhaps even form friendships with — people with whom we strongly disagree?Dax Flame was one of the first YouTube stars. He acted in the movies 21 Jump Street and Project X, and has written three memoirs. After running out of money, he spent a few years working minimum wage jobs, but now at 31 he is attempting to become a full-time YouTuber again. Check out his YouTube channel, @Daxflame. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. Why are colleges and universities valuable to societies? Why does formal post-secondary education seem unnecessary for some fields like programming, where a person can learn everything they need from internet resources? Do universities have a monopoly on credentials? If so, is that monopoly warranted and desirable, or does it stifle innovation and reduce competition? Why have tuition costs been skyrocketing over the past few decades? How does the quantity and quality of university research compare to military and private research? Are universities too political? Should the humanities still be taught in universities? How must colleges and universities evolve to keep pace with technological and economic change?Nicholas Dirks, President and CEO of the New York Academy of Sciences, is an internationally renowned historian and anthropologist. He leads the Academy in promoting science-based solutions to world challenges, including pandemics and global warming. His work at the Academy facilitates the dissemination of scientific information, supports broad access to science education, studies counter bias in academia and the laboratory, and supports scientists across all stages of their careers. He was awarded his Ph.D. from the University of Chicago and has taught at UC Berkeley, the California Institute of Technology, the University of Michigan, and Columbia University. Find him on Facebook, Twitter, LinkedIn, and Instagram. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. What is The Headless Way? What are we like before we accept the names, roles, and narratives given to us by other people? What does it mean for consciousness to be "boundless" or "infinite"? What are the benefits of adopting a "headless" perspective? How can we visit (and feel relatively confident that we've visited) this perspective? Where is this perspective situated relative to the larger constellation of meditation and mindfulness concepts from other traditions?Richard Lang has been teaching The Headless Way for over fifty years having met Douglas Harding, the author of On Having No Head, in 1970. Richard also worked for many years as a psychotherapist as well as teaching tai chi and dance. The Headless Way is a method of waking up to your True Self which is spacious, still, and free. Being conscious of your True Self enables you as an individual to be more creative, loving and effective in the world. Contact Richard at headexchange@gn.apc.org or learn more at his website, headless.org. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]

Read the full transcript here. Can giving people a sense of agency and dignity be better than giving them access to food, shelter, clothing, or cash? And what exactly can be done in practice to expand human agency? How does the value of agency-oriented interventions compare to the value of more tangible interventions? How robust are the findings about all of the above in light of the replication crisis? In general, how much confidence should we place (with or without the replication crisis) in the findings of social science research? How tight should the feedback loop be for organizations that do both research for and implementation of charitable interventions?Richard Sedlmayr works with a private foundation called the Wellspring Philanthropic Fund, where he funds research and innovation to promote pro-poor economic development. He is also involved in the setup of The Agency Fund, a philanthropic partnership investing in ideas and organizations that support people in the navigation of difficult lives. Richard's background is in behavioral, development, and financial economics, and he has a PhD in Public Policy from Oxford. Richard has lived in a dozen countries and is currently based in the Bay Area. You can get in touch with him on LinkedIn. StaffSpencer Greenberg — Host / DirectorJosh Castle — ProducerRyan Kessler — Audio EngineerUri Bram — FactotumWeAmplify — TranscriptionistsMiles Kestran — MarketingMusicBroke for FreeJosh WoodwardLee RosevereQuiet Music for Tiny Robotswowamusiczapsplat.comAffiliatesClearer ThinkingGuidedTrackMind EasePositlyUpLift[Read more]