Good information about vitamins is hard to find. With over 70% of Americans and 40% of Brits using them, it's a hugely lucrative market, which means numerous voices in the media and online pusing a pro-vitamin agenda. All without the scientific evidence to support their claims. So do we need vitamins to lead a healthy life? Or could these supplements actually cause serious health complications?In this episode, Jonathan speaks with Prof. JoAnn Manson and Dr. Sarah Berry to better understand how vitamin supplements affect our health. JoAnn Manson is a professor of epidemiology at the Harvard School of Public Health and one of the world's most cited researchers. She’s run multiple enormous studies with over 20,000 participants to uncover the real effects of vitamin supplementation on our health. Dr. Sarah Berry is one of the world's leading experts on human nutrition, who has personally run over 20 randomized clinical trials looking at how humans respond to different fats. Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide Timecodes:00:00 - Introduction02:29 - Quickfire questions04:27 - Why are people confused about supplements?05:17 - Which supplement does the majority of the population benefit from taking and why?05:51 - What are dietary supplements and vitamins?09:33 - Why is there so much advertising suggesting supplements?10:54 - JoAnn’s research14:07 - About vitamin C15:15 - Megadosing19:51 - VITAL and COSMOS trials25:13 - Should we take vitamin D27:37 - Omega-332:48 - Variation & personalization36:51 - Actionable advice on supplements38:45 - Should children take supplements?42:13 - Should we all take a standard dose multivitamin?44:54 - Summary46:25 - Goodbyes46:57 - OutroEpisode transcripts are available here.Check the trials mentioned in today’s episode: AREDS 2, COSMOS, Physicians' Health Study II, VITALFollow Sarah: https://twitter.com/saraheeberryFollow ZOE on Instagram: https://www.instagram.com/zoe/This podcast was produced by Fascinate Productions.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter JoAnn Manson is a world-renowned endocrinologist, epidemiologist, and Principal Investigator for the Women’s Health Initiative (WHI). In this episode, she dives deep into the WHI to explain the study design, primary outcome, confounding factors, and nuanced benefits and risks of hormone replacement therapy (HRT). JoAnn reflects on how a misinterpretation of the results, combined with sensationalized headlines regarding an elevated risk of breast cancer, led to a significant shift in the perception and utilization of HRT. From there, they take a closer look at the breast cancer data to separate fact from fiction. Additionally, JoAnn gives her take on how one should weigh the risks and benefits of HRT and concludes with a discussion on how physicians can move towards better HRT practices. We discuss: The Women’s Health Initiative: the original goal of the study, hormone formulations used, and potential confounders [4:15]; Study design of the Women’s Health Initiative, primary outcome, and more [16:00]; JoAnn’s personal hypothesis about the ability of hormone replacement therapy to reduce heart disease risk prior to the WHI [26:45]; The relationship between estrogen and breast cancer [30:45]; Why the WHI study was stopped early, and the dramatic change in the perception and use of HRT due to the alleged increase in breast cancer risk [37:30]; What Peter finds most troubling about the mainstream view of HRT and a more nuanced look at the benefits and risks of HRT [45:15]; HRT and bone health [56:00]; The importance of timing when it comes to HRT, the best use cases, and advice on finding a clinician [59:30]; A discussion on the potential impact of HRT on mortality and a thought experiment on a long-duration use of HRT [1:03:15]; Moving toward better HRT practices, and the need for more studies [1:10:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Author Paul Greenberg and scientist JoAnn Manson explore the hype and realities of omega-3 supplements, discussing their origins, impact on health, and sustainability. They highlight the importance of consuming omega-3 rich fish over supplements and balance in dietary choices for optimal health.

Professor JoAnn Manson from Harvard Medical School discusses the lack of benefits of multivitamins in enhancing longevity, with some studies suggesting a 4% increase in mortality risk. The podcast explores the importance of nutrient-deficient diets, risks of megadose supplements, and how to navigate the multivitamin market effectively.

Prof. JoAnn Manson, a prominent researcher in chronic disease and supplements, shares her insights on omega-3 fatty acids and their complex effects on health. She unpacks the VITAL trial's findings, emphasizing how different study designs influence results. The discussion explores varying outcomes of omega-3 trials and their implications for cardiovascular health and cancer prevention. Listeners learn about the importance of tailored supplement recommendations and maintaining a healthy lifestyle, including dietary choices.

Menopause is a time of significant hormonal changes which can lead to a range of symptoms that can severely impact quality of life for many women. So, a drug that promises to reduce these symptoms is incredibly welcome, but it has been steeped in controversy.HRT (Hormone replacement therapy) has been widely debated, with conflicting information about its effectiveness, with some suggesting HRT is outright dangerous. In fact, a massive study twenty years ago linked it to an increased risk of breast cancer. As a result, the numbers of women taking HRT plummeted. So should HRT be avoided at all costs? In today’s episode, Jonathan is joined by the author of that very study and esteemed Professor JoAnn Manson, alongside Dr. Sarah Berry to explore the science behind HRT. Professor JoAnn Manson is a professor of epidemiology at the Harvard School of Public Health and one of the world's most experts on HRT and menopause having run multiple enormous studies to uncover the effects of hormone replacement therapy on women’s health.With the help of ZOE regular Dr. Sarah Berry, they delve into the science behind HRT, empowering listeners to make informed decisions about treatment for symptoms of the menopause.Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguideTimecodes:00:00 Introduction00:12 Jonathan's introduction01:33 Quick Fire Questions03:27 What is the menopause?04:10 What is the perimenopause?05:46 What is the state of the current conversation on the menopause?07:13 Should women seek help about the menopause?07:58 Why do some women have symptoms and others not?09:15 Yougov and ZOE study results on the menopause11:35 Why is the menopause getting more attention now?13:39 Should we be taking these symptoms seriously?17:10 What else can be done asides from HRT?18:49 Studies on the relationship between diet and menopause symptoms19:35 What can help alleviate symptoms?21:23 Are there any specific foods that can help improve symptoms?23:37 Are menopause specific supplements effective?24:50 How does HRT work?26:26 Is HRT just oestrogen?30:59 Does testosterone have a use for menopause?31:58 What is the controversy behind HRT?35:56 What's the latest advice and health risks?38:11 When should you stop hormone therapy?40:43 Do symptoms persist when you come off of hormone therapy?42:00 How long does HRT take to start working?43:07 How does HRT affect weight management?45:15 Summary48:04 Goodbyes48:25 OutroCheck the trials mentioned in today’s episode: MsFlash: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731298/ZOE Menopause Study: https://joinzoe.com/learn/menopause-metabolism-studyPEPI Trial: https://pubmed.ncbi.nlm.nih.gov/7807658/Follow Sarah: https://twitter.com/saraheeberryFollow ZOE on Instagram: https://www.instagram.com/zoe/Episode transcripts are available here.Is there a nutrition topic you’d like us to cover? Get in touch and we’ll do our best to cover it.

Dr. JoAnn Manson, an endocrinologist and professor of medicine at Harvard Medical School, discusses hormone replacement therapy (HRT) after menopause. She explains the pros and cons of HRT, the best types and applications of hormone replacement medications, and the potential health benefits of vitamins and supplements. The podcast also addresses the importance of understanding menopausal changes, the debate between bioidentical and synthetic hormones, and finding the right dose of estrogen for HRT.

Dr. JoAnn Manson, an acclaimed endocrinologist and epidemiologist known for her pivotal role in the Women’s Health Initiative, dives into vital discussions on women's health. She shares how her mother's battle with ovarian cancer fueled her passion for preventative care. The talk explores the complexities of hormone therapy in menopause, emphasizing tailored approaches and the societal shift needed towards prevention. Manson also highlights dietary impacts on breast cancer and heart disease, advocating for lifestyle changes to enhance women's overall well-being.

Dr. JoAnn Manson, a leading researcher in Vitamin D and the VITAL study, joins the discussion to unravel the truth behind this vital nutrient. She explains its importance beyond bone health, potentially influencing cancer and heart risk. Curious about how much Vitamin D you need? Dr. Manson addresses the ideal sources—sunlight, supplements, or both—and shares tips on choosing the best options amidst a crowded market. Plus, she answers common questions about timing, sunscreen, and food interactions, making it a must-listen for health enthusiasts!

Dr. JoAnn Manson, a leading expert from Harvard Medical School, tackles the hype surrounding omega-3 supplements. Are they the miracle cure or just another fad? The discussion uncovers the research behind omega-3s and their real benefits, especially from fish. Dr. Manson also addresses the effectiveness of plant-based sources, the importance of medical supervision for high doses, and clarifies what quality control means for supplements. Plus, listeners get tips for navigating omega-3 sources and meal prep challenges!