Everything You Should Know About Hormone Replacement Therapy, with Dr. JoAnn Manson
Aug 28, 2023
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Dr. JoAnn Manson, an endocrinologist and professor of medicine at Harvard Medical School, discusses hormone replacement therapy (HRT) after menopause. She explains the pros and cons of HRT, the best types and applications of hormone replacement medications, and the potential health benefits of vitamins and supplements. The podcast also addresses the importance of understanding menopausal changes, the debate between bioidentical and synthetic hormones, and finding the right dose of estrogen for HRT.
Hormone therapy should be personalized and tailored to each individual, taking into consideration symptoms and their severity.
FDA-approved bioidentical hormone therapy in non-oral forms, such as transdermal patches, may have advantages over oral pills.
Consultation with a healthcare provider is crucial in determining the best course of action for hormone therapy, considering individual risks and potential benefits.
Deep dives
Different forms of hormone therapy
There are multiple options for hormone therapy, including FDA-approved bioidentical forms such as estradiol and micronized progesterone. These can be administered via transdermal patches or other non-oral routes, which may have advantages over oral pills. It is important to use FDA-approved hormone therapy products for regulated and tested quality. Custom compounding pharmacies may offer non-regulated bioidentical hormone therapy, which can pose risks and should be avoided.
Benefits and risks of hormone therapy
Hormone therapy should be personalized and tailored to each individual. It is not a one-size-fits-all approach. The decision to use hormone therapy should depend on symptoms and their severity. Hot flashes and night sweats, for example, can be managed with hormone therapy for a period of time, typically five to seven years, especially for women in early menopause. The benefits and risks of hormone therapy may vary depending on factors such as age, personal and family medical history, and response to treatment. Shared decision-making between the patient and healthcare provider is crucial in determining the best course of action.
Concerns about hormone therapy
There has been confusion and mixed messaging regarding hormone therapy, particularly due to the results of the Women's Health Initiative study. While hormone therapy can be beneficial for treating moderate to severe menopausal symptoms, it is not recommended for the prevention of chronic diseases, such as heart disease or cognitive decline. Additionally, hormone therapy may carry some risks, including an increased risk of certain health events like blood clots. It is important to consult with a healthcare provider to assess individual risks and discuss the potential benefits and drawbacks of hormone therapy.
Menopause transition and perimenopause
Menopause transition and perimenopause refer to the period leading up to menopause when women may experience irregular menstrual periods and fluctuating hormone levels. The duration of these stages may vary, but on average, perimenopause can last around seven years. During this time, women may experience symptoms such as hot flashes and night sweats. Genitourinary syndrome of menopause, which includes symptoms like vaginal dryness, may persist beyond perimenopause. Treatment options may include hormone therapy, but not all women may require medication. It is essential to consider individual symptoms and preferences when deciding on treatment.
Understanding hormone therapy for menopause
The use of hormone therapy for menopause management is a complex and individualized decision. Hormone therapy can help alleviate symptoms like hot flashes and night sweats, but it should not be used for the prevention of chronic diseases. Bioidentical hormone therapy, when FDA-approved and properly regulated, can be a safe and effective option. However, non-regulated hormones from compounding pharmacies pose risks and should be avoided. The decision to use hormone therapy should be made in consultation with a healthcare provider, considering personal health history and symptom management.
Dr. JoAnn Manson is anendocrinologist, epidemiologist, and professor of medicine at Harvard Medical School, and Brigham and Women's Hospital. In this epsisode, Dr. Manson outlines the specific pros and cons of hormone replacement after menopause, as well as when exactly to start HRT if you choose to pursue it. Find out who is a good candidate for it and who isn’t; what types of hormone replacement medications and applications are best – from bioidentical and synthetic, to pills, gels, creams, patches, etc. She explains the difference between FDA approved medications versus the dangers of custom compounded hormones. Plus, she breaks down the potential health benefits of vitamins and supplements (like folic acid, multi-vitamins, omega 3s, D, B-12, calcium) from pregnancy to menopause!