On Today's Episode: The secret is out… What you eat and consume is tied directly to the majority of the diseases that shorten our lifespan and quality of life. Given that sugar is literally hidden in nearly anything you eat and is everywhere in your local food store, the fight to beat diet-related diseases is tricky.Even when you think you’re eating healthy, chances are there is a sneaky element of poor nutrition at play, which makes medical professionals like Dr. David Perlmutter beyond frustrated. Dr. Perlmutter is a board certified neurologist and fellow with the American College of Nutrition who has published multiple bestselling books on diet and better brain health.This episode is a masterclass on uric acid and its role in metabolic health. It’s possible to fix your diet through good practice, and Dr. Perlmutter is generous with the information he shares that will allow you to make an individualized best assessment for yourself. Your diet and lifestyle are not to be ignored or disregarded for anyone serious about preventing disease.Lack of information leads to unconscious destruction of your gut and havoc being unleashed in your system. Inflammatory problems and metabolic problems can ultimately be addressed with simple, consistent, intentional dietary changes.Some of David’s best advice is to know your uric acid levels and stop eating fructose.Follow David Perlmutter:Website: https://www.drperlmutter.com/Youtube: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQTwitter: https://twitter.com/davidperlmutterInstagram: https://www.instagram.com/davidperlmutter/Are You Ready for EXTRA Impact?If you’re ready to find true fulfillment, strengthen your focus, and ignite your true potential, the Impact Theory subscription was created just for you.Want to transform your health, sharpen your mindset, improve your relationship, or conquer the business world? This is your epicenter of greatness. This is not for the faint of heart. This is for those who dare to learn obsessively, every day, day after day.Subscription Benefits: Unlock the gates to a treasure trove of wisdom from inspiring guests like Andrew Huberman, Mel Robbins, Hal Elrod, Matthew McConaughey, and many, many, more New episodes delivered ad-free Exclusive access to Tom’s AMAs, keynote speeches, and suggestions from his personal reading list You’ll also get access to an 5 additional podcasts with hundreds of archived Impact Theory episodes, meticulously curated into themed playlists covering health, mindset, business, relationships, and more: Legendary Mindset: Mindset & Self-Improvement Money Mindset: Business & Finance Relationship Theory: Relationships Health Theory: Mental & Physical Health Power Ups: Weekly Doses of Short Motivational Quotes  Subscribe on Apple Podcasts: https://apple.co/3PCvJazSubscribe on all other platforms (Google Podcasts, Spotify, Castro, Downcast, Overcast, Pocket Casts, Podcast Addict, Podcast Republic, Podkicker, and more) : https://impacttheorynetwork.supercast.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

What do obesity, insulin resistance, diabetes, fatty liver disease, hypertension, cardiovascular disease, stroke and dementia have in common? They are all chronic diseases that together are the leading cause of death in the world today. And they’re largely caused not by genes, but by our environment, lifestyle and food choices.This much many of us already know. But today’s guest brings some valuable new information to the table: the role of uric acid. Dr David Perlmutter is a board-certified neurologist and six-time New York Times bestselling author. He is on the Board of Directors of the American College of Nutrition and an Associate Professor at the University of Miami Miller School of Medicine. His latest book, Drop Acid: The Surprising New Science of Uric Acid, focuses on the pivotal role of uric acid in chronic metabolic diseases, claiming that lowering its level in the body holds the key to losing weight, controlling blood sugar, and transforming health.Many of us only think about uric acid in relation to a painful condition called gout. But, as David explains even slightly raised uric acid levels, can have damaging and widespread implications for our health. David and I discuss what he calls the ‘evolutionary environmental mismatch’ - how modern lives are at odds with what serves our biology best. And one of the key elements that is driving this mismatch is the modern food environment.Many of us simply think about food as energy or calories but David and I discuss why we need to start thinking about food as information. Every bite that we eat is giving our body cues and signals. If we give our bodies the right cues they will thrive. If we give them the wrong cues they will start to malfunction.We also talk about the relationship between our fructose intake and uric acid levels, the evolutionary benefit for slightly higher uric acid levels, how increased uric acid can drive fat storage, high blood sugar levels, high blood pressure and insulin resistance. We also discuss what changes we can make with our food choices to reduce uric acid levels in our body.David explains how certain food choices can make us more impulsive, less compassionate and less empathetic and how the right food choices can help us make better decisions and increase our happiness. David is a gifted communicator and someone who is committed to helping as many people as possible, live healthier and happier lives. I hope you enjoy listening.Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.Thanks to our sponsors:https://www.seed.com/livemorehttps://www.calm.com/livemorehttps://www.drinkag1.com/livemoreShow notes https://drchatterjee.com/368DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

In this insightful discussion, Dr. David Perlmutter, a renowned neurologist and bestselling author focused on brain health, shares critical insights on preventing and reversing Alzheimer's disease. He explores the link between metabolism and cognitive decline, emphasizing the role of mitochondrial health. Listeners learn how dietary choices, like fructose consumption, and metabolic innovations like GLP-1 drugs can significantly impact brain function. Dr. Perlmutter also highlights the importance of community support and personal experiences in navigating the complexities of Alzheimer's.

Dr. David Perlmutter discusses silent symptoms of dementia and brain decline, emphasizing early lifestyle changes for brain health. Topics include metabolic health indicators, oral microbiome impact on neurodegenerative diseases, Alzheimer's prevention through lifestyle choices, optimizing brain health with diverse activities, importance of glutathione in detoxification, and the connection between long-distance running and atrial fibrillation.

This episode is brought to you by Rupa Health, Thrive Market, and Cozy Earth.Uric acid is a central player in metabolic mayhem. Despite its long association with gout and kidney stones, it’s involved in so much more—especially our metabolic disease epidemic. There are three things that raise our levels of uric acid: purines, alcohol, and fructose. The latter is the biggest challenge, due to its overwhelming presence in our Standard American Diet. That doesn’t mean all fruit is bad or even that all alcohol and purine-rich foods have the same effect. Like all parts of health and nutrition, there are nuances we need to consider to create optimal health.That’s why I’m so excited to take a deep dive into the topic of uric acid with my friend and colleague Dr. David Perlmutter. Dr.Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain among others, and his new book, Drop Acid was just released. Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease and has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.This episode is brought to you by Rupa Health, Thrive Market, and Cozy Earth.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account here. Thrive Market is an online membership-based grocery store that makes eating well convenient and more affordable. Join today to receive an extra 40% off your first order and a free gift worth over $50 here.Cozy Earth makes the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, use code MARK40 to get 40% off your Cozy Earth sheets here.Here are more details from our interview (audio version / Apple Subscriber version):  What is uric acid and how does it affect our health? (5:30 / 2:00)  The impact of fructose consumption on our physiology (11:45 / 8:10)  The differences between fructose and glucose (19:20 / 16:29)  Why high fructose corn syrup is used in so many foods (21:13 / 17:40)  The three sources of uric acid (22:57 / 19:23)  Fructose consumption, uric acid, and gut health (28:19 / 23:43)  How to eat to reduce uric acid (33:54 / 28:52)  Medications that increase uric acid (47:07 / 42:04)   Uric acid and Alzheimer’s (50:28 / 45:28)  Heavy metals, supplements, sleep, exercise, and uric acid (54:12 / 49:14) Get Dr. Perlmutter’s new book, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health here.

Levels Chief Medical Officer, Dr. Casey Means, chatted with our advisor, Dr. David Perlmutter on the discovery of how the elevation of uric acid in the body is a causative mechanism in the development of metabolic diseases, and one of the key links between obesity, diabetes, heart disease, neurologic diseases like dementia, ADHD, fatty liver disease, and more. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl They also covered: The several mechanisms of how uric acid causes cellular dysfunction and insulin resistance, including oxidative stress, inflammation, and even preventing insulin from getting out of the blood stream effectively. The evolutionary reasons why the metabolic dysfunction and weight gain caused by uric acid would have benefitted us historically in terms of low access to food and water, by letting us more easily pack on weight and raise blood pressure. And how we now live in an evolutionary-environmental mismatch where this survival mechanism is now hurting us in the face of caloric abundance. The different dietary and environmental factors that generate uric acid, including fructose, purine rich foods and umami foods, dehydration, alcohol, and more. The optimal levels for uric acid. How uric acid impairs our hunger signals, drives us to eat, and even promotes risk taking behavior. We talked about how to reverse high uric acid levels as a way to unlock optimal health. Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (04:23) - More than just gout (06:17) - A causative role (08:54) - The number one cause of death (16:35) - Evolutionary environmental mismatch (18:08) - High fructose corn syrup (23:39) - The dangers of uric acid (24:49) - Uric acid and dementia (31:44) - Too much fructose (42:43) - Erectile dysfunction and cardiovascular risk (01:04:29) - No need to eat sugar Transcripts & Show Notes

Dr. David Perlmutter, a renowned neurologist, challenges conventional beliefs about Alzheimer's, emphasizing it's more than just genetics—metabolic health is key. He reveals that brain degeneration can start 20 to 30 years before symptoms show. Using engaging analogies, he compares the brain's energy needs to a car engine and highlights the critical role of mitochondria. Dr. Perlmutter advocates for proactive health management, stressing that lifestyle choices significantly impact cognitive health and that many risk factors are within our control.

The elevation of uric acid in the body is a causative mechanism in the development of metabolic diseases and contributes to weight gain and fat production. Uric acid is one of the key links between obesity, diabetes, heart disease, neurologic diseases like dementia, ADHD, non-alcoholic fatty liver disease, and more. Dr. David Perlmutter talks with Dr. Casey Means about why we have excess uric acid, what foods cause uric acid production, and what simple steps we can take to lower our uric acid levels to be optimal. Look for multiple new shows per week on A Whole New Level, where we have in-depth conversations about metabolic health and how the Levels startup team builds a wellness movement from the ground up in the health and wellness tech industry. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠ They also cover: How uric acid causes cellular dysfunction and insulin resistance, including oxidative stress, and inflammation, and even prevents insulin from getting out of the bloodstream effectively. Why uric acid would have benefitted us evolutionarily in terms of low access to food and water by letting us more easily pack on weight and raise blood pressure—but how that fights against us today because we now live in an evolutionary-environmental mismatch where this survival mechanism hurts us in the face of caloric abundance. The different dietary and environmental factors that generate uric acid, including fructose, purine-rich foods and umami foods, dehydration, alcohol, and more. How uric acid impairs our hunger signals, drives us to eat, and even promotes risk-taking behavior. How to reverse high uric acid levels as a way to unlock optimal health. 🎙 What Dr. David Perlmutter & Dr. Casey Means discuss: (04:23) - More than just gout (06:17) - A causative role (08:54) - The number one cause of death (16:35) - Evolutionary environmental mismatch (18:08) - High fructose corn syrup (23:39) - The dangers of uric acid (24:49) - Uric acid and dementia (31:44) - Too much fructose (42:43) - Erectile dysfunction and cardiovascular risk (01:04:29) - No need to eat sugar Transcripts & Show notes 🔗 Helpful links: Watch the conversation: https://youtube.com/watch?v=QZ6jPCcFNa8 Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1 📲 Connect: Connect with Dr. Casey Means on Instagram: https://instagram.com/DrCaseysKitchen Connect with Casey on Twitter: https://instagram.com/DrCaseysKitchen Connect with David Perlmutter, MD on Instagram: https://instagram.com/davidperlmutter Connect with David on Twitter: https://twitter.com/DavidPerlmutter Connect with David on LinkedIn: https://linkedin.com/in/david-perlmutter-md-6a38b930

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Structured PH-Balanced Alkaline Water: https://www.ameolife.com or call 1-8-0-0-4-2-2-8-1-4-8, use code DAVE20 to get 20% offMattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProIN THIS EPISODE OF THE HUMAN UPGRADE™...… guest Dr. David Perlmutter explains how he’s an expert in dropping acid, but not in the way you might think. A regular contributor to groundbreaking science, he’s back on the show to talk about why you should be paying attention to your uric acid levels. Dr. Perlmutter is a neurologist and five-time New York Times bestselling author. His books include “Brain Wash,” “Grain Brain” and  “Brain Maker.” He’s recognized internationally as a leader in the field of nutritional influences in neurological disorders. Now, he’s turning his attention to how uric acid threatens your metabolic health.Uric acid is a waste product of metabolism, and its levels are a key health marker and indicator of chronic degenerative diseases. When uric acid levels rise, they tell your body to store fat, which messes with your metabolism and poses a danger to your health.Alcohol, purines (breakdown product of DNA and RNA in foods) and fructose (the kind of sugar found in processed foods) are the three main sources of uric acid. Since the days of our primate ancestors, we’ve lost the ability to break down uricase, so what we choose to consume makes a big difference.“If we can emulate those signals to our DNA and our physiology that have evolved to keep us healthy,” Dr. Perlmutter says, “we're going a long way to offsetting these incredibly powerful metabolic disruptions that are paving the way for the biggest cause of disease on our planet.”His newest book, “Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health,” includes ways to measure, control and track your uric acid levels and key strategies to manage them. You’ll find out the top five foods that raise uric acid (hint: fructose earns the No. 1 spot). You’ll also find out the five important supplements to take to lower your uric acid levels back into a healthy range.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today’s guest is Dr. David Perlmutter, who is a Board-Certified Neurologist and five-time New York Times bestselling author. He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award and he currently serves on the Board of Directors and is a Fellow of the American College of Nutrition. He’s written a new book Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health.In this episode we discuss how your diet can contribute to your behavior, the real reason most people are addicted to sugar, how to reduce the risk of Alzheimers and other diseases, the emerging science behind uric acid and everything you need to know about its effects on the body, and so much more!For more go to: www.lewishowes.com/1211Check out Perlmutter's website - www.drperlmutter.comRead his new book - www.dropacidbook.comThe Wim Hof Experience: Mindset Training, Power Breathing, and Brotherhood: https://link.chtbl.com/910-podA Scientific Guide to Living Longer, Feeling Happier & Eating Healthier with Dr. Rhonda Patrick: https://link.chtbl.com/967-podThe Science of Sleep for Ultimate Success with Shawn Stevenson: https://link.chtbl.com/896-pod  Get more from Lewis! Pre-order my new book Make Money EasyGet The Greatness Mindset audiobook on SpotifyText Lewis AIYouTubeInstagramWebsiteTiktokFacebookX