The Proof with Simon Hill

Is high cholesterol always a problem? | Nick Norwitz, PhD

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Jul 23, 2024
Guest
Nick Norwitz
Nick Norwitz, Oxford PhD graduate and Harvard Medical student, explores high cholesterol debates including Oreos vs statins, lean mass hyper-responders, and cholesterol management. Topics cover a self-experiment study with Oreos, managing statin discussions, debunking health claims, and personal health journeys like ulcerative colitis and the ketogenic diet.
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INSIGHT

Leanness Amplifies LDL Response

  • Lean Mass Hyper Responders (LMHRs) raise LDL much more on ketogenic diets the leaner they are.
  • This response contrasts metabolic syndrome patients, who tend not to elevate LDL with carb restriction.
INSIGHT

LMHR: Unique Lipid Triad

  • LMHR phenotype has high LDL, high HDL, and low triglycerides, a unique lipid triad.
  • This differs from typical high LDL with low HDL and high triglycerides seen in metabolic dysfunction.
INSIGHT

Carbs Drop LDL Via Glycogen

  • Adding carbohydrates back to a LMHR repletes liver glycogen, reducing fat fuel trafficking and dropping LDL rapidly.
  • This is why Oreos lowered LDL in Nick Norwitz's experiment despite being considered 'unhealthy'.
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