Is high cholesterol always a problem? | Nick Norwitz, PhD

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Jul 23, 2024

Nick Norwitz, Oxford PhD graduate and Harvard Medical student, explores high cholesterol debates including Oreos vs statins, lean mass hyper-responders, and cholesterol management. Topics cover a self-experiment study with Oreos, managing statin discussions, debunking health claims, and personal health journeys like ulcerative colitis and the ketogenic diet.

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Intro

00:00 • 3min

Exploring Diverse Perspectives in Science

03:06 • 4min

Exploring Uncertainty and Unique Phenotypes in Lipidology

06:52 • 11min

Effects of Oreo Cookies on Cholesterol Levels

18:15 • 15min

Navigating Academic Conversations and Communicating Scientific Concepts

33:10 • 2min

Challenges of LDL Management and Medical Mistrust

35:27 • 7min

Navigating Controversial Conversations and Misinterpretations in Health Discourse

42:40 • 20min

Exploring proper hydration, electrolyte replenishment, and a brief touch on climate change

01:02:52 • 2min

Exploring the Impact of Agriculture on Climate Change and Metabolism

01:04:23 • 15min

Understanding the Complexities of Cholesterol Levels and Cardiovascular Risk

01:19:37 • 22min

Challenges and Victories with Dietary Interventions

01:41:41 • 10min

Decisions in Managing Cholesterol Levels

01:52:08 • 22min

Examining Diets for Autoimmune Conditions

02:14:07 • 20min

Exploring Views on Lipid Lowering Medications and their Impact on Cardiovascular Health

02:34:21 • 2min

Lipid Energy Model and Lean Mass Hyper Responders

02:36:44 • 18min

Exploring Long-Term Ketogenic State and Health Implications

02:54:26 • 14min

Coronary CT Study on Lean Mass Hyper-Responders

03:08:36 • 11min

Exploring the Effects of Fermented Foods and Fiber on the Microbiome and Inflammation

03:19:18 • 3min

Research on Saturated Fats and Cardiovascular Health

03:21:57 • 9min

Engaging Education Through Creative Storytelling and Linguistic Precision

03:30:34 • 2min

Exploring All-Cause Mortality and Insights from Recent Lectures

03:32:24 • 2min

Discussion on APOB Impact and Lean Mass Hyper-responder Phenotype

03:34:05 • 6min

Importance of Constructive Dialogues and Engagement in Discussions

03:39:49 • 7min

Physiological Impact of Carbohydrate Reintroduction on Cholesterol Levels

03:47:01 • 16min

Understanding APO B and its Implications on Cardiovascular Risk

04:02:52 • 19min

Impact of Lipid Lowering Medications on Mortality in Type 2 Diabetes

04:21:29 • 26min

Exploring the Unknown Benefits of Lowering APOB and Engaging the Audience in Fun Challenges

04:47:30 • 1min

Pushup fundraising and baking for charity

04:48:57 • 4min

Personal Conversations and Marathon Stories

04:52:34 • 3min

Episode #323. Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health.

You’ll learn about Dr Norwtiz’s health journey, including his experience with inflammatory bowel disease and the ketogenic diet. We discuss cholesterol management and cardiovascular disease risk, lean mass hyper-responders, and statins. This episode is an important and informative reflection on scientific curiosity and misinformation.

Specifically, we discuss:

Introduction (00:00:00)
The Importance of Curiosity in Scientific Progress (04:39)
Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders (08:52)
Scientific and Clinical Impact of the Oreo Study (25:03)
Addressing Criticisms and Misinterpretations of the Study (34:47)
Navigating Statin Discussions on Social Media (40:27)
Debunking Claims About PCSK9 Inhibitors (53:18)
Challenging Misinformation in Health Communities (59:15)
The Lipid Energy Model and Lean Mass Hyper Responders Explained (01:06:59)
Defining Lean Mass Hyper Responders: Key Terminology (01:14:19)
Practical Advice for Lean Mass Hyper Responders (01:30:35)
The Carnivore Kid: An Intriguing Case Study (01:41:48)
Personal Struggles with Ulcerative Colitis and Starting Keto (01:45:24)
Balancing Medication and Personal Health Choices (01:50:31)
Debating Dietary Interventions for Inflammatory Bowel Disease (02:11:09)
Challenges in Dietary Research and Medical Interventions (02:25:55)
Introducing the Lipid Energy Model and Its Mechanisms (02:34:49)
Debating the Validity of the Lipid Energy Model (02:44:29)
Long-Term Effects of Ketosis and Carb Restriction (02:52:31)
Critiques and Limitations of the Lipid Energy Model (02:57:17)
ApoB-Containing Lipoproteins and Atherosclerosis (03:03:50)
Current Research and Future Directions on LMHR (03:06:41)
Exploring Inflammatory Responses to Fibre (03:16:12)
The Link Between Saturated Fats and Heart Disease (03:20:49)
Closing Thoughts on Effective Scientific Communication (03:25:29)
The Lean Mass Hyper Responders Debate: Addressing Frustrations (03:32:32)
Understanding Carbohydrate Reintroduction Physiology (03:46:58)
Diet-Specific Strategies to Lower ApoB (03:55:16)
Examining Claims About ApoB and Cardiovascular Disease (04:01:50)
Trade-offs in Lowering ApoB Levels (04:12:54)
Exploring the Link Between All-Cause Mortality and ApoB (04:22:42)
Lean Mass Hyper Responders and ApoB: A Unique Profile (04:44:54)
Concluding Thoughts and Future Discussion Topics (04:48:10)

Connect with Nick Norwitz, PhD on Twitter/X, Instagram, and YouTube. Make sure to check out the full show notes for additional resources and supporting studies.

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill