Discussion on APOB Impact and Lean Mass Hyper-responder Phenotype

Episode #323. Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health.

You’ll learn about Dr Norwtiz’s health journey, including his experience with inflammatory bowel disease and the ketogenic diet. We discuss cholesterol management and cardiovascular disease risk, lean mass hyper-responders, and statins. This episode is an important and informative reflection on scientific curiosity and misinformation.

Specifically, we discuss:

• Introduction (00:00:00)
• The Importance of Curiosity in Scientific Progress (04:39)
• Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders (08:52)
• Scientific and Clinical Impact of the Oreo Study (25:03)
• Addressing Criticisms and Misinterpretations of the Study (34:47)
• Navigating Statin Discussions on Social Media (40:27)
• Debunking Claims About PCSK9 Inhibitors (53:18)
• Challenging Misinformation in Health Communities (59:15)
• The Lipid Energy Model and Lean Mass Hyper Responders Explained (01:06:59)
• Defining Lean Mass Hyper Responders: Key Terminology (01:14:19)
• Practical Advice for Lean Mass Hyper Responders (01:30:35)
• The Carnivore Kid: An Intriguing Case Study (01:41:48)
• Personal Struggles with Ulcerative Colitis and Starting Keto (01:45:24)
• Balancing Medication and Personal Health Choices (01:50:31)
• Debating Dietary Interventions for Inflammatory Bowel Disease (02:11:09)
• Challenges in Dietary Research and Medical Interventions (02:25:55)
• Introducing the Lipid Energy Model and Its Mechanisms (02:34:49)
• Debating the Validity of the Lipid Energy Model (02:44:29)
• Long-Term Effects of Ketosis and Carb Restriction (02:52:31)
• Critiques and Limitations of the Lipid Energy Model (02:57:17)
• ApoB-Containing Lipoproteins and Atherosclerosis (03:03:50)
• Current Research and Future Directions on LMHR (03:06:41)
• Exploring Inflammatory Responses to Fibre (03:16:12)
• The Link Between Saturated Fats and Heart Disease (03:20:49)
• Closing Thoughts on Effective Scientific Communication (03:25:29)
• The Lean Mass Hyper Responders Debate: Addressing Frustrations (03:32:32)
• Understanding Carbohydrate Reintroduction Physiology (03:46:58)
• Diet-Specific Strategies to Lower ApoB (03:55:16)
• Examining Claims About ApoB and Cardiovascular Disease (04:01:50)
• Trade-offs in Lowering ApoB Levels (04:12:54)
• Exploring the Link Between All-Cause Mortality and ApoB (04:22:42)
• Lean Mass Hyper Responders and ApoB: A Unique Profile (04:44:54)
• Concluding Thoughts and Future Discussion Topics (04:48:10)

Connect with Nick Norwitz, PhD on Twitter/X, Instagram, and YouTube. Make sure to check out the full show notes for additional resources and supporting studies.

This episode is brought to you by:

38TERA

Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

Eimele

Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.

LMNT

Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill