378: How to Build an Alzheimer's-Resistant Brain and Reduce Cognitive Decline | Lisa Mosconi, PhD
Mar 13, 2024
auto_awesome
Neuroscientist Lisa Mosconi discusses strategies to build an Alzheimer's-resistant brain, including lifestyle adjustments and water quality. The podcast explores the impact of nutrition and lifestyle choices on brain health and emphasizes the importance of cognitive reserve through exercise, diet, sleep, and intellectual challenges. It also delves into the role of menopause in brain health, addressing symptoms, hormone replacement therapy controversies, and the need for evidence-based approaches.
Manage existing medical conditions to support brain health.
Individualize hormone replacement therapy discussions for women's brain health.
Understanding menopause's neurological effects is crucial for cognitive function.
Deep dives
Dementia Prevention for Men and Women
Manage existing medical conditions affecting brain health, make lifestyle adjustments according to individual risks, and focus on managing menopause for women to reduce Alzheimer's risk.
Impact of Menopause on the Brain
Menopause triggers neurological changes leading to symptoms such as hot flashes, memory lapses, and fatigue, affecting brain health. The neurological effects of menopause can vary significantly among women and should be addressed to support cognitive function.
Hormone Replacement Therapy (HRT) and Brain Health
HRT was fraught with controversy due to the Women's Health Initiative that linked HRT to increased health risks. Recent studies show conflicting results, with some indicating benefits for brain health, while others suggesting potential risks. Individualized discussions with healthcare providers on HRT necessity and risks are crucial.
Challenges and Misconceptions about HRT
Misinformation and misconceptions surrounding HRT, especially regarding breast cancer risk, present challenges for women considering HRT. Understanding the contextualized risks and benefits, as well as individualized recommendations based on comprehensive assessments, is essential for informed decision-making.
Research on Hormone Impact on Dementia Risk
A meta-analysis on the impact of hormones on dementia risk was conducted, involving over six million women globally. The study revealed that the type of hormone formulation and when it is taken significantly affect the risk of Alzheimer's disease. For women with a uterus, taking estrogen and progesterone within 10 years of menopause reduces the risk by 32%, whereas delaying hormone use does not show the same risk reduction.
Evolutionary Perspective on Menopause
Menopause in human females is compared to other species that undergo this transition such as whales, elephants, and some giraffes. An evolutionary theory suggests that menopause serves as a way for older women to focus on helping their offspring reproduce and pass on their genes. Neurological changes during menopause affect empathy, emotional control, and happiness, highlighting potential post-menopausal benefits in emotional regulation and contentment.
LifeForce is a powerful, at-home biomarker testing solution (they test important biomarkers like ApoB, LDL, A1C, hormones, and more!). Head to MyLifeForce.com and use code GENIUS for 15% off.
BUBS Naturals makes my favorite collagen, pure and unflavored, perfect for mixing into any drink, soup, or even recipes! Your hair, skin, and nails will thank you. Visit BUBSNaturals.com and use code GENIUS for 20% off.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode