Core IM | Internal Medicine Podcast #53 Heparin-Induced Thrombocytopenia: 5 Pearls Segment
40 snips
Nov 13, 2019 AI Snips
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HIT Risks
- Untreated Heparin-Induced Thrombocytopenia (HIT) carries a substantial daily risk.
- This risk includes thrombosis, amputation, and even death.
HIT Pathophysiology
- HIT involves antibody-mediated platelet activation triggered by heparin exposure.
- This process forms complexes involving heparin, platelet factor 4, and an antibody.
HIT Onset
- Rapid-onset HIT occurs immediately after heparin exposure in previously exposed patients.
- Typical-onset HIT develops after 5-10 days, allowing time for antibody formation.