
Live Like a Girl with Dr. Mindy Pelz Your Brain on Ketones: The New Science Linking Metabolic Health, Mental Health, and the Power of Ketosis with Dr. Georgia Ede
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Apr 8, 2026 Dr. Georgia Ede, a Harvard-trained psychiatrist and leader in nutritional psychiatry, explores how ketones and metabolic health shape brain function. She discusses the brain as a hybrid engine using glucose and ketones. Topics include links between insulin resistance and mood disorders, ketone targets for serious mental illness, overnight ketosis for brain repair, menopause and brain metabolism, and practical paths to achieve ketosis.
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Depression As Brain Energy Shortage
- Depression can reflect an energy shortage in the brain that powers it down.
- When the brain can't turn glucose into energy smoothly it reduces motivation, sleep, and activity, producing depressive symptoms.
Test Fasting Insulin Not Just Glucose
- Check fasting insulin not just fasting glucose to detect early metabolic dysfunction.
- Aim for fasting insulin below 10 µIU/mL (ideally ≤6) because higher values indicate excess insulin production and carbohydrate intake.
Aim For Overnight Mild Ketosis
- Use both glucose and ketones because the brain is a hybrid engine and functions best on a mixture of fuels.
- Encourage mild overnight ketosis so the brain can enter healing mode, perform repair, and reduce inflammation.




