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Huberman Lab
Journal Club With Dr. Peter Attia | Metformin for Longevity & the Power of Belief Effects
Sep 11, 2023
Dr. Peter Attia, a physician trained at Stanford and Johns Hopkins, shares his insights as the host of The Drive and author of 'Outlive.' He and the host dive deep into the potential of metformin for enhancing longevity and its fascinating ties to diabetes management. They explore the influence of belief on health outcomes, revealing how mindset can alter drug effects. The conversation emphasizes understanding scientific literature, the role of glucose monitoring, and the delicate balance between lifestyle choices and health impacts.
02:18:52
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Quick takeaways
- Metformin's potential role as an anti-aging drug is still uncertain due to conflicting study results and confounding factors.
- Critically analyzing scientific research through journal clubs helps verify and evaluate claims made in scientific papers.
Deep dives
Metformin and its potential role in longevity
This podcast episode discusses the potential benefits of metformin, a drug commonly used to treat type 2 diabetes, in terms of lifespan and longevity. The episode references a previous study by banister that found a 15% reduction in all-cause mortality among individuals with type 2 diabetes who took metformin. The study was limited by informative censoring and differences in medication usage between groups. A new study by keys and colleagues aimed to replicate and expand on these findings. They used a larger sample size and included a twin group to account for genetics and shared environment. The results showed that individuals with type 2 diabetes who took metformin had a higher crude mortality rate compared to those without diabetes. However, the study's limitations and confounding factors make it difficult to draw definitive conclusions on metformin's role in longevity. The episode highlights the ongoing TAME trial, which aims to further investigate metformin's potential as an anti-aging drug.
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