#317 How to Support Muscle Health for Longevity and Improving Metabolism | Dr. Gabrielle Lyon

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Oct 1, 2025

Dr. Gabrielle Lyon, a physician and founder of the muscle-centric medicine movement, shares her expertise on muscle health and longevity. She discusses why muscle is essential for metabolic health and resilience, offering insights into how muscle influences brain function and mood. Dr. Lyon emphasizes the importance of a protein-rich diet and practical resistance training, even for busy lifestyles. She also dives into the implications of GLP-1s on muscle and provides tips for effective training, highlighting that prioritizing muscle can alter your health trajectory.

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INSIGHT

Muscle As The Organ Of Longevity

Skeletal muscle is the organ of longevity and underlies metabolic strength.
Muscle determines resilience, disease risk, mobility and aging outcomes.

INSIGHT

Muscle Releases Systemic Hormones

Muscle is an endocrine organ that releases myokines affecting brain, metabolism and bone.
These signals link muscle directly to mood, cognition, glucose control and bone health.

ANECDOTE

Geriatrics Training Shaped Her View

Lyon trained in nutritional sciences then did a geriatrics fellowship to study muscle and aging.
Seeing many frail, declining patients shifted her view on the importance of muscle for longevity.

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In this episode, we’re cutting through the noise around strength, longevity, and weight loss with Dr. Gabrielle Lyon, a physician and founder of the muscle-centric medicine movement.

If you’ve ever wondered how to train for long-term health, this is your practical, science-backed guide. We dive into why building and maintaining muscle is essential not just for performance or appearance but for your metabolic health, brain function, immune system, and resilience as you age.

We cover:

💪 Why muscle is the organ of longevity and how it protects against chronic disease

🥗 What a muscle-centric plate looks like

🧠 How muscle influences your mood, memory, and brain health

🏋️‍♀️ The minimum effective dose of resistance training for busy lives

Plus, Dr. Lyon answers your biggest questions about GLP-1s, sarcopenia, protein, supplements, and how men and women should train differently as they age.

If you’re in your 30s, 40s, or beyond and haven’t prioritised muscle this conversation might just change your health trajectory.

Dr. Gabrielle Lyon is an accomplished physician and the New York Times bestselling author of FOREVER STRONG: A New, Science-Based Strategy for Aging Well.

Dr. Lyon's educational and research background includes dual clinical fellowships in geriatrics and nutritional sciences at Washington University, along with undergraduate training in nutritional sciences at the University of Illinois. A highly sought-after educator and consultant, she is an authority in the practical application of protein types and levels for health, performance, aging, and disease prevention. You can find out more from Dr Lyon here at https://drgabriellelyon.com/