This Podcast Will Kill You

Ep 108 Gout: Toetally fascinating

Oct 25, 2022
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ANECDOTE

Sydenham's Gout Description

  • Thomas Sydenham's vivid 17th-century description of a gout attack, detailing the excruciating pain and progression of symptoms, perfectly illustrates the classic gout experience.
  • This account, sourced from "Gout, The Patrician Malady," sets the stage for exploring gout's historical perception and evolution.
INSIGHT

Gout: Known Mechanisms, Unknown Causes

  • Gout, a form of inflammatory arthritis, is caused by monosodium urate crystal deposits in joints, triggering an inflammatory response.
  • While the mechanism is clear, the underlying reasons why some individuals develop gout while others with similar crystal deposits do not remain largely unknown.
INSIGHT

Evolutionary Quirk of Urate

  • Humans have higher urate levels than other mammals due to an evolutionary quirk: the loss of uricase, an enzyme that breaks down uric acid.
  • While potentially beneficial as an antioxidant or in blood pressure regulation, this high urate level predisposes humans to gout.
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