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Sydenham's Gout Description
- Thomas Sydenham's vivid 17th-century description of a gout attack, detailing the excruciating pain and progression of symptoms, perfectly illustrates the classic gout experience.
- This account, sourced from "Gout, The Patrician Malady," sets the stage for exploring gout's historical perception and evolution.
Gout: Known Mechanisms, Unknown Causes
- Gout, a form of inflammatory arthritis, is caused by monosodium urate crystal deposits in joints, triggering an inflammatory response.
- While the mechanism is clear, the underlying reasons why some individuals develop gout while others with similar crystal deposits do not remain largely unknown.
Evolutionary Quirk of Urate
- Humans have higher urate levels than other mammals due to an evolutionary quirk: the loss of uricase, an enzyme that breaks down uric acid.
- While potentially beneficial as an antioxidant or in blood pressure regulation, this high urate level predisposes humans to gout.