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Alzheimer's Pathology
- Alzheimer's disease kills brain cells (neurons) and shrinks brain tissue.
- It also involves misprocessed proteins like amyloid and tau, forming deposits in the brain.
Amyloid Hypothesis
- The amyloid hypothesis suggests amyloid plaques are central to Alzheimer's, similar to cholesterol in heart disease.
- Genetic evidence and the toxicity of amyloid fragments support this idea.
Colombian Family Study
- Dr. Tariot and colleagues studied a Colombian family with a genetic mutation causing early-onset Alzheimer's.
- The goal was to test preventative therapies before significant brain damage.