Alzheimer's - Is Amyloid a Cause of Cognitive Loss?

This is sort of a question about causation. The hope has been that mitigating this abnormal processing pathway in the right way at the right time will result in less amyloid burden in the brain. And maybe we can slow down the clinical chug or not. If you intervene before any significant brain changes have occurred, if you intervene with an anti-amyloid therapy, can you stave off clinical manifestations?