Wellness + Wisdom Podcast Inherited Trauma: The Hidden Reason Depression Runs In Your Family
Jan 13, 2026
Dr. Brad Currier, a clinical scientist focused on mitochondrial health, dives into how mitochondrial decline impacts aging and mood. He reveals the significance of maternal mitochondrial inheritance and the role of environmental factors in cellular health. Dr. Currier discusses Urolithin A, a postbiotic that enhances cellular energy and combat age-related decline. He emphasizes the importance of exercise and targeted supplementation for longevity and shares insights into the gut-brain axis affecting mood and cognition. Discover how simple lifestyle changes can lead to significant health improvements.
01:05:55
Maternal Inheritance Shapes Cellular Energy
- Mitochondria are inherited exclusively from the biological mother and contain their own DNA separate from the nucleus.
- This maternal inheritance sets an initial mitochondrial 'starting point' that influences energy production across life.
Environment Directly Impacts Mitochondrial Power
- Mitochondria convert food substrates into ATP and are directly affected by environmental inputs.
- Pollutants, poor food quality, and toxins converge on mitochondria and reduce cellular energy production.
Protect Mitochondria From Sun Damage
- Be mindful of UV exposure since UV damages cellular proteins including those in mitochondria.
- Take countermeasures when interacting with environmental risks to protect mitochondrial function.
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Intro
00:00 • 1min
Maternal Inheritance of Mitochondria
01:12 • 1min
What Mitochondria Do
02:29 • 1min
Environmental Threats to Mitochondria
03:53 • 1min
Key Environmental Risks: Sun and Pollution
05:12 • 3min
Intergenerational Mitochondrial Effects
08:31 • 4min
Nature vs. Nurture for Mitochondria
12:40 • 59sec
Why Cells Age: Accumulation and Slower Turnover
13:39 • 4min
Autophagy and Mitophagy Explained
17:41 • 1min
Urolithin A: Discovery and Role
19:04 • 5min
Why Most People Can't Make Urolithin A
24:30 • 2min
Gut Microbiome Damage and Diversity Loss
26:20 • 35sec
Gut-Brain Axis and Mitochondria
26:55 • 3min
When Food Alone Isn’t Enough
29:53 • 3min
Mitopure Uniquely Activates Mitophagy
32:30 • 3min
Evidence Standards and Timeline's Research
35:30 • 2min
Expectations: Gradual Cellular Benefits
37:22 • 58sec
Mitochondria, Mood, and Cognition
38:20 • 5min
Cognition Study Hypothesis and Design
43:00 • 5min
Stacking Mitopure with Exercise
47:38 • 3min
Exercise Drives Mitochondrial Benefits
50:40 • 3min
Daily Habits for Healthspan
53:56 • 6min
Staying Comfortable with Discomfort
59:39 • 3min
Future Directions: Beyond Muscle and Brain
01:02:50 • 2min
Outro
01:04:33 • 1min
#2115
• Mentioned in 18 episodes
It didn't start with you
Mark Wolynn
Ludivine Bouton-Kelly
In 'It Didn't Start with You,' Mark Wolynn explores how unresolved trauma can be passed down through generations and affect our lives in profound ways.
The book provides practical steps and techniques to identify and heal from these inherited traumas, helping readers to break the cycle and improve their well-being.
#1110
• Mentioned in 31 episodes
Outwitting the Devil
The Secret to Freedom and Success
Sharon Lechter
Napoleon Hill
Written in 1938 by Napoleon Hill, 'Outwitting the Devil' was considered too controversial to be published in its era.
The book is presented as an interview between Hill (Mr.
Earthbound) and the devil (our inner dark self), where Hill uncovers the secrets to freedom and success by evaluating the greatest obstacles humans face in achieving their personal goals.
The book discusses topics such as the difference between drifters and non-drifters, maintaining a definiteness of purpose, finding one’s other self, Hill’s seven principles, and the law of hypnotic rhythm.
Annotated and edited for a contemporary audience by Sharon Lechter, it was finally published in June 2011.
Is mitochondrial decline the hidden blueprint that decides how fast your body ages?
Josh Trent welcomes Dr. Brad Currier, PhD, Clinical Scientist, to the Wellness + Wisdom Podcast, episode 793, to unpack how mitochondrial health is passed through generations, why modern environments and sedentary living accelerate aging, how mitophagy and Urolithin A restore cellular energy, why gut health blocks or enables longevity, and how exercise plus targeted supplementation can fundamentally shift mood, vitality, and long term health from the inside out.
30% Off Mitopure (Timeline Nutrition)The first clinically tested Urolithin A supplement
Mitopure® is a highly pure form of Urolithin A, a postbiotic clinically shown to energize cells, increase muscle strength, and improve endurance. And this is just the beginning. New studies continuously explore and prove the incredible potential of Urolithin A.
Few people can get enough Urolithin A from diet alone. Mitopure unlocks 6X the dose of Urolithin A when compared to dietary sources such as pomegranate juice, without the sugar.
Mitochondria, our cellular powerhouses, are constantly renewed to fulfill the vast energy demands of cells. As we age, mitochondrial function declines, starting as early as our 30s. Mitopure stimulates the mitochondrial renewal process to protect cells from age-associated decline.
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In This Episode, Dr. Brad Currier Uncovers: [01:10] How to Optimize Mitochondrial Health- How our mitochondrial DNA is passed from mothers to children.
- The functions of mitochondria in the human body.
- How our environment affects our mitochondria.
- Why UV radiation from the sun damages proteins in our cells.
- How sedentary lifestyle impact mitochondrial health.
Resources:
[08:35] Intergenerational Mitochondrial Health- How mitochondrial health is impacted by multiple generations that came before us.
- Why we're impacted by seven generations before us, and we impact seven generations after us.
- The importance of nurturing our mitochondrial health.
Resources:
[12:55] The Cause of Aging- What causes faster aging.
- How our cells become unhealthy and age.
- Why our cell turnover slows down as we age.
- How mitochondria break down and impact our energy levels.
Resources:
[16:55] The Importance of Urolithin A- The role of postbiotics in digestion.
- Why we need Urolithin A for optimal health.
- How Urolithin A was discovered.
Resources:
[20:55] You Need to Fix Your Microbiome- Why we have to take supplements to maintain our health.
- How the microbiome blocks production of Urolithin A.
- Why most people's gut microbiome is damaged.
- How our gut microbiome lacks diversity compared.
- How the gut-brain axis is linked to many diseases.
- Why mitochondria can impact different systems of the body.
- The importance of supplementing Urolithin A.
- Why food cannot help us produce more Urolithin A.
- How aging affects protein absorption.
- Why Mitopure is the only clinically proven supplement to activate mitophagy.
- The three phases of the mitochondria's life cycle.
- Why removing cellular residue prevents aging.
- How healthy mitochondria can help us live a better life.
- Why renewing cellular energy requires consistency.
- How mitochondrial health impacts mood and mental health.
- Why Timeline Nutrition continues running new clinical studies.
- How repeated scientific research proves whether something truly works or not.
- Why they publish all of their studies online.
- Why professional athletes have a higher risk of heart attack.
- How exercise is the best tool for health and longevity.
- Why combining Mitopure with exercise increases mitochondrial health.
- How weightlifting helps us create new cells.
- How Brad takes care of his own health.
- Why exercise is the most important tool for him.
- The role of a good diet and sleep in our health.
- Why change can feel counterintuitive at first.
- The importance of allowing ourselves to feel uncomfortable.
- How we can't often know for sure what tools or supplements are best for us.
"Poor quality food and pollutants in our environment ultimately converge on the mitochondria and have an impact on its ability to produce energy. When we have this accumulation of debris in our cells, they don't work as well and they start releasing toxins that impact cells around them. " — Dr. Brad Currier, PhD
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Brad Currier, PhD, is a clinical scientist specializing in mitochondrial health, cellular aging, and metabolic resilience.
With a background in translational research and applied clinical science, Brad focuses on how mitochondria, lifestyle inputs, and environmental stressors influence energy production, longevity, and disease risk.
His work bridges cutting-edge science with real-world application, helping people understand how to protect and optimize their cellular engines for sustained health, performance, and resilience.