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Colistin Use
- Only use colistin as a last resort if newer beta-lactam agents are unavailable.
- Testing is difficult, and it's very toxic, so consider BLBLIs or cefiderocol first.
Colistin Effectiveness
- Colistin is not only toxic but also ineffective, a point often underappreciated.
- A colistin disk elution test is available if broth microdilution isn't accessible.
Colistin Testing Issues
- Colistin susceptibility testing has a high risk of false susceptibility.
- The FDA doesn't clear any colistin testing methods, making it difficult.