Boost Your Biology with Lucas Aoun

152. Megadosing L-Theanine For HARDCORE Anxiety & Stress Relief (Solocast)

Apr 14, 2023
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INSIGHT

L-Theanine Basics And Caffeine Stacking

  • L-theanine is a non-protein amino acid in green tea that pairs well with caffeine to reduce jitters and improve focus.
  • Typical stack is 200 mg L-theanine to 100 mg caffeine and users report calmer focus and lower blood pressure from caffeine.
INSIGHT

How L-Theanine Works In The Brain

  • L-theanine acts as a glutamate receptor antagonist and stimulates GABA and glycine release, shifting neurotransmission toward calm.
  • It also triggers dopamine and serotonin release and may influence neurogenesis via SIC38A1 and mTOR pathways.
ANECDOTE

Personal 1000 mg 'Megadose' Experience

  • Lucas tried a 1000 mg L-theanine powder dose at midday and felt mellow within 20–30 minutes with reduced perceived stress and blunted anticipatory excitement.
  • He experienced reduced motivation, improved verbal fluency, less rumination, lowered appetite and blood pressure, slight dissociation, physical weakness, and very deep sleep that night.
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