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Dr. Ghanum discusses the bidirectional relationship between gut health, microbiome, and brain health. He explains that the gut and brain communicate with each other and can influence various aspects of mental well-being. Dr. Ghanum highlights research indicating links between imbalances in the microbiome, inflammation, and conditions like autism and neurodegenerative diseases. He also mentions the impact of stress reduction, exercise, and maintaining a healthy lifestyle in supporting a balanced gut-brain axis and overall brain health.