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The episode highlights how hormonal fluctuations during perimenopause can significantly affect cognitive function, particularly in women. Many women experience symptoms like memory loss and difficulty concentrating due to changes in estrogen and progesterone levels. Research indicates that approximately 40 to 60 percent of women report cognitive complaints during this transition, with memory issues being the most prevalent. This cognitive decline is linked to the ways hormonal changes interact with brain function, evidenced by studies showing that women undergoing surgical menopause and not receiving estrogen experience greater memory decline.