Raj Shamani's Figuring Out

Insulin Resistance Explained: Diabetes, PCOS & Weight Gain | Karan Sarin | FO465 Raj Shamani

Jan 31, 2026
Karan Sarin, author and metabolic health coach who studies insulin resistance and public‑health trends. He breaks down why insulin resistance drives diabetes, PCOS and hidden weight gain. Short, clear takes on TOFI (thin outside, fat inside), why Indian diets spike insulin, ketogenic approaches, better grains, and links between metabolic dysfunction and brain health.
Ask episode
AI Snips
Chapters
Books
Transcript
Episode notes
INSIGHT

Metabolic Dysfunction Is A Clustered Crisis

  • India faces a clustered metabolic dysfunction linking diabetes, heart disease, fatty liver and early fertility problems.
  • Karan Sarin calls insulin resistance the common denominator driving these connected diseases.
ADVICE

Reduce Frequent Carb Loads

  • Reduce frequent carbohydrate loads across the day to avoid chronically high insulin.
  • Stop constant snacking and sugary tea/tea‑with‑biscuits habits that keep insulin elevated.
INSIGHT

Skin Changes Signal Insulin Problems

  • Visible skin tags and dark velvet neck patches are clear, non‑lab signs of insulin resistance.
  • Karan Sarin links these growth changes to insulin's anabolic (growth) effects on skin.
Get the Snipd Podcast app to discover more snips from this episode
Get the app