Insulin Resistance Explained: Diabetes, PCOS & Weight Gain | Karan Sarin | FO465 Raj Shamani
Raj Shamani's Figuring Out
The Thin‑Outside Fat‑Inside Phenomenon
Karan explains the TOFI phenotype and why BMI is a poor metabolic health marker for Indians.
Guest Suggestion Form:
https://forms.gle/bnaeY3FpoFU9ZjA47
Disclaimer: This video is intended solely for educational purposes and opinions shared by the guest are his personal views. We do not intent to defame or harm any person/ brand/ product/ country/ profession mentioned in the video.
Our goal is to provide information to help audience make informed choices. The media used in this video are solely for informational purposes and belongs to their respective owners.
Order 'Build, Don't Talk' (in English) here: https://amzn.eu/d/eCfijRu
Order 'Build Don't Talk' (in Hindi) here: https://amzn.eu/d/4wZISO0
Follow Our Whatsapp Channel: https://www.whatsapp.com/channel/0029VaokF5x0bIdi3Qn9ef2J
Subscribe To Our Other YouTube Channels:-
https://www.youtube.com/@rajshamaniclips
https://www.youtube.com/@RajShamani.Shorts
(00:00) - Intro
(2:51) - Metabolic Dysfunction
(7:00) - What Is Insulin Resistance?
(18:58) - Progression of Insulin Resistance
(25:10) - Signs That You Are Insulin Resistant
(32:40) - TOFI – The “Thin Outside, Fat Inside” Phenomenon
(37:27) - Why Indians Store Most Fat in Visceral Areas
(45:52) - Why Your Body Doesn’t Need Carbohydrates
(57:53) - The Ketogenic Diet
(1:00:12) - Why Are Carbohydrates Such a Big Part of Our Diet If They Aren’t Essential?
(1:07:21) - Two Grains That Are Better Than Wheat
(1:14:25) - What Is Type 3 Diabetes?
(1:18:46) - What Is Type 4 Diabetes?
(1:25:17) - The Three Big Rocks of Metabolic Health
(1:32:49) - Focus on High-Protein Diets
(1:35:46) - BTS
(1:36:38) - Outro
In today’s episode, we have Karan Sarin, author of Sick Nation, breaking down why India is facing a silent metabolic epidemic.
The conversation goes deeper into the coming dementia crisis in India, insulin resistance as a hidden driver of PCOS, and why erectile dysfunction can be an early warning sign of metabolic damage. We also discuss how chronic stress quietly destroys metabolic health, veg vs non-veg diets from a metabolic lens, and the three most important levers to fix metabolic health.
This episode is essential for anyone serious about long-term health, energy, and disease prevention.
Subscribe for more such conversations.
Follow Karan Sarin Here:
Instagram: https://www.instagram.com/sweetreactions
About Raj Shamani
Raj Shamani is an Entrepreneur at heart that explains his expertise in Business Content Creation & Public Speaking. He has delivered 200+ speeches in 26+ countries. Besides that, Raj is also an Angel Investor interested in crazy minds who are creating a sensation in the Fintech, FMCG, & passion economy space.
To Know More,Follow Raj Shamani On ⤵︎
Instagram @RajShamani https://www.instagram.com/rajshamani/
Twitter @RajShamani https://twitter.com/rajshamani
Facebook @ShamaniRaj https://www.facebook.com/shamaniraj
LinkedIn - Raj Shamani https://www.linkedin.com/in/rajshamani/
About Figuring Out
Figuring Out Podcast is a Candid Conversations University where Raj Shamani brings raw conversations with the Top 1% in India.
The AI-powered Podcast Player
