Insulin Resistance Explained: Diabetes, PCOS & Weight Gain | Karan Sarin | FO465 Raj Shamani
Raj Shamani's Figuring Out
The Compensatory Phase and Beta-Cell Exhaustion
Karan describes hyperinsulinemia, pancreas compensation over years, then beta-cell failure and progression to diabetes.
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(00:00) - Intro
(2:51) - Metabolic Dysfunction
(7:00) - What Is Insulin Resistance?
(18:58) - Progression of Insulin Resistance
(25:10) - Signs That You Are Insulin Resistant
(32:40) - TOFI – The “Thin Outside, Fat Inside” Phenomenon
(37:27) - Why Indians Store Most Fat in Visceral Areas
(45:52) - Why Your Body Doesn’t Need Carbohydrates
(57:53) - The Ketogenic Diet
(1:00:12) - Why Are Carbohydrates Such a Big Part of Our Diet If They Aren’t Essential?
(1:07:21) - Two Grains That Are Better Than Wheat
(1:14:25) - What Is Type 3 Diabetes?
(1:18:46) - What Is Type 4 Diabetes?
(1:25:17) - The Three Big Rocks of Metabolic Health
(1:32:49) - Focus on High-Protein Diets
(1:35:46) - BTS
(1:36:38) - Outro
In today’s episode, we have Karan Sarin, author of Sick Nation, breaking down why India is facing a silent metabolic epidemic.
The conversation goes deeper into the coming dementia crisis in India, insulin resistance as a hidden driver of PCOS, and why erectile dysfunction can be an early warning sign of metabolic damage. We also discuss how chronic stress quietly destroys metabolic health, veg vs non-veg diets from a metabolic lens, and the three most important levers to fix metabolic health.
This episode is essential for anyone serious about long-term health, energy, and disease prevention.
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About Raj Shamani
Raj Shamani is an Entrepreneur at heart that explains his expertise in Business Content Creation & Public Speaking. He has delivered 200+ speeches in 26+ countries. Besides that, Raj is also an Angel Investor interested in crazy minds who are creating a sensation in the Fintech, FMCG, & passion economy space.
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About Figuring Out
Figuring Out Podcast is a Candid Conversations University where Raj Shamani brings raw conversations with the Top 1% in India.
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