Psychiatry & Psychotherapy Podcast
Adverse Childhood Experiences - HPA axis & Brain changes: cortisol, amygdala, hippocampus, cytokines, & epigenetics (Part 3 of ACE series)
Jul 19, 2024
Delve into the lasting effects of Adverse Childhood Experiences on the brain and body, from impacting the HPA axis to inflammation and neurobiology. Explore how childhood trauma can lead to changes in cortisol response, brain regions like the hippocampus and amygdala, and inflammatory cytokines. Understand the link between FKBP5 protein, cortisol regulation, and mental health disorders, and discover the importance of therapeutic interventions in mitigating the negative impacts of early life stress on mental health.
01:26:59
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Quick takeaways
- ACEs affect the HPA axis, cortisol response, and neurobiology, contributing to psychiatric disorders.
- Epigenetic changes due to ACEs impact stress response, mental health, and gene expression.
Deep dives
Adverse Childhood Experiences and Their Long-Term Impact on Health
Adverse childhood experiences can lead to changes in the hypothalamic-pituitary-adrenal axis, resulting in a more blunted cortisol response to stress. These experiences can also lead to epigenetic changes in glucocorticoid receptor genes and alterations in brain structure, such as decreased hippocampal volume and white matter integrity. Additionally, childhood trauma is associated with increased inflammatory cytokines, heightened amygdala reactivity, and reduced activity in the reward system, impacting long-term health.
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