Differences in Depression Types and HPA Axis Activity

The chapter delves into the differences between individuals with high inflammation levels and melancholic depression, comparing symptoms, HPA axis activity, and responses to stress. It discusses treatment guidelines for different types of depression, along with the impact of cortisol and CRH on anxiety, depression, and addictive behaviors. The chapter also explores epigenetic modifications in the glucocorticoid receptor gene NR3C1 due to factors like maltreatment and early life stress, emphasizing the significance of studying biological changes in the brain for suicide predisposition.