ACR Journals On Air
Immunology for the Rheumatologist: NETs in Lupus
Jan 21, 2025
Dr. Mariana Kaplan, Chief of the Systemic Autoimmunity Branch at NIAMS and a leading lupus researcher, dives into the intriguing world of Neutrophil Extracellular Traps (NETs) in systemic lupus erythematosus. She explains how NETs and Low-Density Granulocytes contribute to inflammation and tissue damage in lupus patients. The discussion highlights potential biomarkers for disease activity and their implications for diagnosis and treatment, emphasizing the link between lupus and cardiovascular risks. Kaplan also shares her inspiring journey in tackling autoimmune diseases.
40:02
Episode guests
AI Summary
AI Chapters
Episode notes
Podcast summary created with Snipd AI
Quick takeaways
- Neutrophil Extracellular Traps (NETs) play a crucial role in exacerbating inflammation and tissue damage in lupus patients.
- Low-Density Granulocytes (LDGs) are associated with increased disease activity and cardiovascular complications, highlighting lupus patients' unique risks.
Deep dives
Understanding Lupus Diagnosis and Cardiovascular Risks
The diagnosis of lupus can be challenging due to its heterogeneous symptoms, which often include fatigue, joint pain, and skin rashes. A clinical case study of a 31-year-old woman reveals how her initial symptoms were linked to an upper respiratory infection and led to a lupus diagnosis alongside preclinical atherosclerosis and dyslipidemia. Laboratory findings showed inflammation markers, autoantibody presence, and elevated cholesterol levels, emphasizing the connection between lupus and cardiovascular disease. This highlights the urgent need to bridge gaps in understanding the biological pathways contributing to lupus-related cardiovascular risks.
Remember Everything You Learn from Podcasts
Save insights instantly, chat with episodes, and build lasting knowledge - all powered by AI.
