Dr. Mariana Kaplan, Chief of the Systemic Autoimmunity Branch at NIAMS and a leading lupus researcher, dives into the intriguing world of Neutrophil Extracellular Traps (NETs) in systemic lupus erythematosus. She explains how NETs and Low-Density Granulocytes contribute to inflammation and tissue damage in lupus patients. The discussion highlights potential biomarkers for disease activity and their implications for diagnosis and treatment, emphasizing the link between lupus and cardiovascular risks. Kaplan also shares her inspiring journey in tackling autoimmune diseases.