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9min chapter
Immunology for the Rheumatologist: NETs in Lupus
ACR Journals On Air
Neutrophil Extracellular Traps in Lupus
This chapter explores the complex role of neutrophil extracellular traps (NETs) in the immune response associated with lupus, emphasizing how NET formation can both drive inflammation and expose autoantigens. It discusses the impaired clearance of NETs in lupus patients and the contributions of factors like low-density granulocytes and immune complexes. The chapter also examines the implications of NET-related tissue damage in lupus and the ongoing research into potential therapeutic approaches.
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