Fast. Feast. Repeat. Intermittent Fasting For Life

Episode 124: Leptin Resistance and Insulin Levels, Fasting Length and Fat Burning, and More

Nov 12, 2025

Discover how high insulin levels create leptin resistance and disrupt appetite regulation. Learn about the effects of leptin on health and its hormonal interactions, particularly during menopause. A listener shares inspiring weight loss success and strategies for breaking plateaus, including adjusting eating windows. The hosts provide practical advice on maintaining fasting schedules amidst busy lifestyles and offer insights into the importance of motivation for sustained fasting. Plus, tips on incorporating supplements wisely during your eating window!

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INSIGHT

Insulin Blocks Leptin Signaling

High insulin blocks the brain from sensing leptin, causing leptin resistance and persistent hunger despite ample fat stores.
Lowering insulin via clean fasting restores leptin sensitivity and enables appetite correction.

ADVICE

Prioritize The Clean Fast

Maintain a clean fast to keep insulin low and let your body sense stored fat accurately.
Avoid caloric or protein-containing beverages during fasting to preserve appetite correction.

INSIGHT

Modern Diet Creates Leptin Resistance

Leptin is produced by fat cells and signals the brain about fat stores, but modern chronic high insulin causes leptin resistance.
Intermittent fasting plus whole real foods lowers insulin and restores satiety signaling.

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Welcome to this week’s episode of Fast. Feast. Repeat. Intermittent Fasting for Life, with Gin Stephens and Sheri Bullock.
To make a submission for the podcast, go to fastfeastrepeat.com/submit. We are a community-driven podcast, and we look forward to sharing your questions, success stories, non-scale victories, IF tweaks, motivational quotes (and more!) on each episode of the podcast.
Resources used in today’s episode: Fasting sweet spot graph: https://share.icloud.com/photos/030s2ptnQNkwyEnj3BvHnJNIg https://www.bertherring.com/not-hungry-vs-full-the-difference-can-cause-relentless-weight-gain/
To get the books, go to https://www.ginstephens.com/get-the-books.html. The second edition of Delay, Don’t Deny is now available in ebook, paperback, hardback, and audIo book. This is the book that you’ll want to start with or share with others, as it is a simple introduction to IF. It’s been updated to include the clean fast, a thorough description of ADF and all of your ADF options, and an all new success stories section. When shopping, make sure to get the second edition, which has a 2024 publication date. The audiobook for the second edition is also available now!
Want to learn more about BiOptimizer’s Magnesium Breakthrough? Visit www.bioptimizers.com/fastfeastrepeat and use code FFR15 to save 15% off any order.
Go to fastfeastrepeat.com to see Gin’s and Sheri’s favorite things, and to shop with us. Every purchase you make through links on our website help to support this podcast so we can keep bringing you episodes each week.
Are you ready to take your intermittent fasting lifestyle to the next level? There’s nothing better than community to help with that. In the Delay, Don’t Deny community we all embrace the clean fast, and there’s just the right support for you as you live your intermittent fasting lifestyle.
Connect with both Gin and Sheri in the community, as well as thousands of other intermittent fasters who are there to support you along your journey. If you’re new to intermittent fasting or recommitting to the IF lifestyle, join the 28-Day FAST Start group. After your fast start, join us for support in The 1st Year group. Need tips for long term maintenance? We have a place for that! There are many more useful spaces beyond these, and you can interact in as many as you like.
Visit ginstephens.com/community to join us. An annual membership costs just over a dollar a week when you do the math. If you aren’t ready to fully commit for a year, join for a month and you can cancel at any time. If you know you’ll want to stay forever, we also have a lifetime membership option available.
IF is free. You don’t need to join our community to fast. But if you’re looking for support from a community of like-minded IFers, we are here for you at ginstephens.com/community.