The Tim Ferriss Show

#650: Dr. Matthew Walker, All Things Sleep — How to Improve Sleep, How Sleep Ties Into Alzheimer’s Disease and Weight Gain, and How Medications (Ambien, Trazodone, etc.), Caffeine, THC/CBD, Psychedelics, Exercise, Smart Drugs, Fasting, and More Affect Sleep

1246 snips
Jan 19, 2023
Dr. Matthew Walker, a neuroscience professor and sleep expert, dives deep into the science of sleep. He discusses how lack of sleep is linked to Alzheimer's and weight gain, emphasizing the need for quality rest. Walker explores intriguing topics like the effects of caffeine, THC, and psychedelics on sleep, offering practical tips for better sleep hygiene. He shares insights into sleep aids, the nuances of narcolepsy, and how sleep deprivation can disrupt appetite. Overall, it's a compelling exploration of how sleep impacts our health and wellbeing.
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INSIGHT

Sleep and Alzheimer's

  • Sleep deprivation increases beta-amyloid and tau, proteins linked to Alzheimer's.
  • Deep sleep clears these proteins via the glymphatic system, a brain-cleaning process.
ADVICE

Deep Sleep Decline

  • Deep sleep decline begins in your 30s, earlier for men than women.
  • This decline correlates with brain atrophy affecting sleep-generating regions.
INSIGHT

Ubiquity of Sleep

  • Sleep, or a sleep-like state, is present in every species studied, from mammals to insects.
  • This suggests sleep is fundamental for survival and may have predated wakefulness.
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