Overlooked and Shockingly Simple Tools to Assess and Mitigate the Risk of Alzheimer’s Disease with Dr. David Perlmutter

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Aug 4, 2025

In this engaging dialogue, Dr. David Perlmutter, a renowned neurologist and bestselling author, unveils the long-term factors influencing Alzheimer’s risk. He emphasizes that simple measurements like belly size can reveal metabolic health. The impact of diet is crucial; colorful foods outshine refined carbs in brain benefits. Dr. Perlmutter advocates for brain-boosting activities and innovative tools to assess brain metabolism. Discover why early lifestyle changes are pivotal for a healthier future!

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INSIGHT

Belly Fat Signals Brain Health

Belly fat measurement reveals metabolic dysfunction and inflammation risk.
This simple measure correlates well with brain health prognosis.

INSIGHT

Blood Sugar Directly Impacts Brain

Blood sugar levels under 100 mg/dL are needed for optimal brain health.
Elevated levels in normal range correlate with brain shrinkage and dementia risk.

ADVICE

Eat Colorful Veggies, Avoid Refined Carbs

Avoid refined carbs and processed grains to maintain blood sugar control.
Fill your diet with colorful vegetables and fiber for brain and metabolic health.

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This episode is brought to you by Momentous and AquaTru.

According to today’s guest, the roots of Alzheimer’s are planted decades before symptoms appear. That means it’s never too early to take action. Today’s guest, Dr. David Perlmutter, shares powerful lifestyle strategies to protect your brain and lower your risk of neurodegenerative disease.

Today on The Dhru Purohit Show, we’re revisiting one of our most talked-about moments with Dr. David Perlmutter to discuss research on the top four factors that can determine the risk of developing Alzheimer’s and his lifestyle tips for prevention. Dr. Perlmutter shares the tools we can use to analyze our brain’s energy use and discusses the importance of engaging in physically and mentally stimulating activities.

Dr. David Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain and Drop Acid. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease. He has published extensively in peer-reviewed scientific journals, including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.

In this episode, Dhru and Dr. Perlmutter dive into:

How belly measurements can reveal metabolic health (01:21)
Four key factors that determine Alzheimer’s risk (6:00)
The impact of refined carbs vs. colorful foods on brain health (8:10)
How blood pressure and nitric oxide affect cognitive function (11:08)
The surprising connection between the oral microbiome and brain health (19:54)
Tools to assess how efficiently the brain uses energy (22:54)
How a sedentary lifestyle increases the risk of cognitive decline (25:12)
Final thoughts and takeaways (27:34)

Also mentioned:

Full episode with Dr. David Perlmutter

This episode is brought to you by Momentous and AquaTru Shower.

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