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The Root Cause Medicine Podcast

The Frontiers of Endothelial Glycocalyx and Cardiovascular Health with Dr. Tom Guilliams

Aug 14, 2023
Dr. Tom Guilliams, the Director at Point Institute and Adjunct Associate Professor at the University of Wisconsin School of Pharmacy, discusses the secrets of the endothelial glycocalyx and potential biomarkers for assessing glycocalyx activity. They delve into the role of the glycocalyx in cardiovascular health, lifestyle factors that support endothelial health, and insights for maintaining cardiovascular health.
45:41

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • The glyco-calix, a layer of carbohydrates and proteins that coats the endothelial cells, plays a crucial role in regulating blood flow, reducing inflammation, and preventing clot formation in the cardiovascular system.
  • Lifestyle factors such as exercise, stress reduction, and a diet rich in antioxidants and phytonutrients can contribute to maintaining the health of the glyco-calix and endothelial function.

Deep dives

Glyco-Calix and Endothelial Health

The glyco-calix, a layer of carbohydrates and proteins that coats the endothelial cells in our arteries, veins, and capillaries, plays a crucial role in maintaining endothelial health. This layer acts as a gatekeeper, regulating blood flow, reducing clot formation, and preventing inflammation. Disruption or dysfunction of the glyco-calix can lead to endothelial dysfunction, increasing the risk of cardiovascular diseases. Research is being conducted to explore biomarkers and test methods for measuring the health of the glyco-calix. While specific tests are not yet available, markers such as inflammation, glycation, and pressure can indicate potential glyco-calix damage. Lifestyle factors such as exercise, stress reduction, and a diet rich in antioxidants and phytonutrients can contribute to glyco-calix and endothelial health. Supplementation with nutrients like vitamin C and botanical extracts, as well as specific carbohydrates found in seaweed, may also help support and enhance the glyco-calix.

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