Morgan Levine, PhD, is an assistant professor at Yale School of Medicine and a founding investigator at Altos Labs, specializing in epigenetic aging. In this conversation, she unveils the revolutionary PhenoAge clock, explores the impact of lifestyle on biological aging, and discusses the potential for reversing age through interrupted reprogramming techniques. Levine also highlights how inflammation influences epigenetic aging, and reveals insights on the reliability of consumer epigenetic tests and the promising role of plasma exchange in combating age-related decline.
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insights INSIGHT
Aging Types
Biological age matters more than chronological age.
Biological age reflects the body's internal changes and health status, not just years lived.
insights INSIGHT
Biological Aging Fundamentals
Biological aging is fundamental and starts at the molecular level.
Changes in molecules and cells accumulate, impacting tissues and organs, causing noticeable decline.
insights INSIGHT
Epigenetics as an Operating System
Epigenetics, like a cell's operating system, gets rewritten with age.
This rewriting impacts cell function and could drive aging.
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True Age by Dr. Morgan Levine delves into the latest developments in aging and longevity science, providing insights into biological age and strategies to slow down or reverse aging. The book offers personalized plans for lifestyle changes such as diet, exercise, and sleep, along with practices like intermittent fasting to enhance healthspan.
Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging.
Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.
In this episode, Dr. Levine and I discuss:
(00:00) Introduction to Dr. Morgan Levine
(01:19) What is aging and why does it matter to scientists?
(04:45) Hallmarks of aging
(08:59) The advantage of epigenetic clocks in research
(19:05) Epigenetic age acceleration
(36:40) Are epigenetic changes in aging a cause or consequence?
(42:15) Reversing epigenetic age with interrupted reprogramming techniques
(49:27) Therapeutic plasma exchange in aging and pro-aging factors in blood
(56:01) Lifestyle factors that accelerate epigenetic age
(01:03:23) Reliability of consumer epigenetic aging tests
(01:06:12) Construct validity of epigenetic clocks
(01:12:06) Thoughts on most exciting research in aging field
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