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Huberman Lab

Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping

Sep 19, 2022
Explore nicotine's intriguing effects on the brain, enhancing focus and alertness while tempting users with its addictive nature. Discover the various delivery methods, from smoking to vaping, and their unique experiences and risks. Gain insights into the neurochemical impact behind nicotine, including its role in dopamine and norepinephrine action. Learn effective strategies for quitting, including clinical hypnosis and alternative replacements, catering to the massive audience eager to kick the habit.
01:50:24

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Quick takeaways

  • Nicotine activates the mesolimbic reward pathway, increasing dopamine levels and enhancing focus and concentration.
  • Nicotine suppresses appetite and increases metabolism, resulting in slight calorie burning.

Deep dives

Nicotine's effects on the brain

Nicotine activates the mesolimbic reward pathway, increasing dopamine levels and providing feelings of motivation and pleasure. It also increases acetylcholine, enhancing focus and concentration. Additionally, nicotine stimulates the release of norepinephrine, boosting alertness and energy.

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