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CAR-T Are Living, Self‑Expanding Drugs
- CAR-T are engineered T cells with chimeric antigen receptors that persist and expand in vivo.
- Their antigen-driven expansion creates a living drug that amplifies anti-tumor immunity.
Plan For Manufacturing Delays
- Remember CAR-T products are autologous and made from the patient's own apheresed cells.
- Expect a 2–6 week manufacturing window during which patients may need bridging therapy.
Viral Vectors Can Trigger False HIV Tests
- Lentiviral/retroviral vectors used to transduce CAR constructs contain HIV-derived sequences.
- Certain HIV NAT assays can detect vector sequences and produce false-positive results after CAR-T.