The Diary Of A CEO with Steven Bartlett Moment 209: The Real Reason You’re Gaining Weight (Even If You’re Exercising!)
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Apr 18, 2025 
Join geneticist Giles Yeo, an expert in obesity and eating behavior, as he unveils the science behind weight gain and your metabolism. He explains how genes influence hunger and why your body clings to fat, particularly as you age. Yeo challenges the notion that exercise is a silver bullet for fat loss, discussing its limited effectiveness. He also shares practical strategies for sustainable weight management that go beyond common misconceptions, highlighting the importance of resistance training and understanding your body's natural 'set point'.
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Ethnicity Affects Disease Risk
- Different ethnic groups have varied susceptibility to diseases related to body weight, like diabetes and cardiovascular disease.
- Body shape and fat distribution also influence disease risk distinctively among ethnicities.
Obese Gene Influences Hunger
- The obese gene (leptin gene) signals fat amount to the brain and mutations can affect hunger and weight.
- Mutations in the MC4R gene make some people on average 40 pounds heavier by 18 due to altered hunger signals.
Body Weight Set Thermostat
- Everyone has a weight "thermostat" or range their body defends, making significant weight loss hard to maintain.
- Small fluctuations happen, but it's difficult to shift body weight far below your natural set range sustainably.
