Moment 209: The Real Reason You’re Gaining Weight (Even If You’re Exercising!)
Apr 18, 2025
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Join geneticist Giles Yeo, an expert in obesity and eating behavior, as he unveils the science behind weight gain and your metabolism. He explains how genes influence hunger and why your body clings to fat, particularly as you age. Yeo challenges the notion that exercise is a silver bullet for fat loss, discussing its limited effectiveness. He also shares practical strategies for sustainable weight management that go beyond common misconceptions, highlighting the importance of resistance training and understanding your body's natural 'set point'.
Genetic factors significantly influence an individual's propensity for weight gain, indicating that biology plays a crucial role in dieting success.
Maintaining muscle mass through resistance training is essential for healthy aging and managing weight, especially as metabolism changes with age.
Deep dives
Genetic Influences on Eating and Disease Risk
Genetic factors play a significant role in how individuals respond to food, eating habits, and their risk of obesity and related diseases. For instance, it has been observed that people from certain ethnic backgrounds, such as South Asians and East Asians, are more susceptible to type 2 diabetes at lower body mass indices compared to other groups, highlighting the interplay between genetics and cultural dietary habits. The discussion also points to specific genes, such as the leptin gene, which regulates hunger signals from the brain, and the MC4R gene, mutations of which can predispose individuals to obesity. These genetic predispositions contribute to varying degrees of difficulty for individuals in maintaining or losing weight, suggesting that biology plays a crucial role in dietary behaviors.
The Set Point Theory and Personal Weight Range
The concept of a 'set point' or weight range, which each individual naturally defends, indicates that maintaining a certain body weight can be influenced heavily by genetics. This means that some people may find it easier to sustain their weight within a particular range, while others struggle significantly to achieve or maintain lower weights. Factors influencing this set point include the body's metabolic processes and how individuals respond to fluctuations in diet and exercise. Even with conscious dietary changes, it is often challenging for people to achieve desired weight loss beyond their natural range without extensive effort and lifestyle alterations.
Muscle Mass as a Key to Healthy Aging
As individuals age, maintaining muscle mass becomes crucial for overall health and well-being, independent of body weight. Contrary to outdated thoughts that metabolism declines around age 40, recent evidence suggests that metabolic rates generally dip around age 60, with lifestyle factors such as decreased physical activity contributing to weight gain earlier. Emphasizing resistance training and muscle preservation not only aids in managing weight but also enhances physical capabilities as one ages, enabling them to remain active and avoid mobility limitations. This focus on muscle health as a priority supports the notion that prioritizing strength over sheer weight can lead to healthier aging and better quality of life.
Tried everything to lose weight and nothing’s working? It’s not your fault. According to geneticist Giles Yeo, your body is hardwired to hold onto fat—especially as you age. Yeo breaks down why your metabolism slows, how your genes shape your hunger, and why exercise isn’t the fat-loss fix you think it is. If you’ve been eating better, moving more, and still not seeing results… this is the science-backed reality check you’ve been waiting for.