The Tim Ferriss Show #838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello
In this lively conversation, the duo explores the intriguing 2–2–2 drinking rule for moderation. They dive into the potential of bioelectric medicine and share personal experiences with accelerated TMS. The discussion turns to Alzheimers, highlighting innovative sleep drugs and metabolic strategies for cognitive health. With a keen eye on AI, they analyze its rapid evolution and investment opportunities. Personal anecdotes on modern dating and unique gift recommendations add a light-hearted touch to the mix.
01:51:56
Practical Drinking Guardrails
- Use the 2–2 rule: max two drinks per night, never two nights in a row, and two days a week.
- Reserve alcohol for celebrations to prevent habitual consistency that creates cravings.
Accelerated TMS Breakthrough
- Tim tried accelerated TMS with precision targeting using resting-state fMRI for anxiety and saw dramatic short-term relief.
- The first treatment reduced his generalized anxiety to near zero for three to four months.
DCS May Unlock Compressed TMS
- D-cycloserine (DCS) can potentiate TMS, possibly by enhancing neuroplasticity, allowing compressed protocols.
- Combining DCS with hourly stimulation produced one-day effects in Tim's case.
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Intro
00:00 • 2min
Anthony DeMello and alcohol philosophy
01:59 • 2min
The 2–2–2 drinking rule
03:32 • 4min
Tim's bioelectric medicine interest
07:16 • 1min
Accelerated TMS: Tim's experience
08:38 • 5min
Using D-cycloserine to boost TMS
13:13 • 4min
Funding research and bioelectric future
17:11 • 2min
Ad break
19:16 • 2min
Aphantasia discovery
21:08 • 12min
DORA sleep drugs and Alzheimer's risks
33:20 • 6min
Alzheimer's testing and prevention strategies
39:17 • 5min
Ad break
43:56 • 1min
State of AI: rapid iteration
45:16 • 4min
Google, Gemini, and chip stacks
49:16 • 6min
VC, product-market-fit, and AI-era startups
54:52 • 4min
Investment themes for AI era
59:12 • 3min
Ad break
01:02:05 • 1min
Holiday gift ideas and small favorites
01:03:13 • 7min
Books: Anthony DeMello and fiction picks
01:09:55 • 10min
Personal AI assistants and Notion agents
01:20:22 • 8min
Oboe and learning automation
01:27:53 • 4min
Tim's relationship and modern dating
01:32:11 • 12min
Closing thoughts and holiday sign-offs
01:44:40 • 4min
Outro
01:48:19 • 4min
#16813
• Mentioned in 2 episodes
Stop Fixing Yourself
Anthony de Mello
#3569
• Mentioned in 11 episodes
Fierce Intimacy
Terrence Real
#432
• Mentioned in 55 episodes
The End of Alzheimer's
The First Program to Prevent and Reverse Cognitive Decline
Dale Bredesen
In this book, Dr. Dale Bredesen presents a revolutionary program that fundamentally changes how we understand and treat Alzheimer’s disease.
He argues that Alzheimer’s is not one condition but three distinct conditions, each impacting the brain differently.
The book outlines 36 metabolic factors (including micronutrients, hormone levels, and sleep) that can trigger cognitive decline and provides a detailed protocol, known as ReCODE, to rebalance these factors through lifestyle modifications such as diet, supplementation, exercise, and brain training.
The approach emphasizes the importance of addressing multiple 'holes' in brain health to prevent and reverse cognitive decline.
#803
• Mentioned in 35 episodes
Excellent Advice for Living
Wisdom I Wish I'd Known Earlier
Kevin Kelly
Excellent Advice for Living is a compilation of Kevin Kelly's life wisdom, initially written for his young adult children on his 68th birthday.
The book features 450 aphorisms that cover a wide range of topics, from setting ambitious goals and optimizing generosity to cultivating compassion and practical advice on career, relationships, parenting, and finances.
Kelly's advice is designed to be accessible and applicable to all ages, emphasizing the importance of kindness, decency, and generosity of spirit.
The book is praised for its straightforward and memorable guidance, making it an ideal companion for anyone seeking to navigate life with grace and creativity.
#3937
• Mentioned in 10 episodes
Gold
Rumi
Haleh Liza Gafori
This book features a groundbreaking translation of Rumi’s poetry by Haleh Liza Gafori.
Rumi’s poems are meant to bring readers to a condition of serenity, compassion, and oneness with the divine.
Gafori’s translations preserve the intelligence and drama of the original Farsi text, offering a fresh and urgent interpretation of Rumi’s spiritual quest.
The poems, sourced from the Diwan-e Shams-e Tabrizi, are arranged to capture the springy, mantric effect of the original ghazals, inviting readers to embrace a more enlightened existence through love and ecstasy.
#36
• Mentioned in 236 episodes
Why We Sleep
Matthew Walker
This book delves into the purpose and power of sleep, explaining how it affects every aspect of our physical and mental well-being.
Walker discusses how sleep enriches our ability to learn, memorize, and make logical decisions, recalibrates our emotions, restocks our immune system, fine-tunes our metabolism, and regulates our appetite.
He also explores the consequences of sleep deprivation and provides actionable steps to improve sleep quality, including ways to prevent cancer, Alzheimer’s, and diabetes, slow the effects of aging, and increase longevity.
#1122
• Mentioned in 28 episodes
Tomorrow, and Tomorrow, and Tomorrow
Gabrielle Zevin
Spanning thirty years, 'Tomorrow, and Tomorrow, and Tomorrow' by Gabrielle Zevin is a sweeping narrative that explores the lives of Sam and Sadie, two friends united by their love of video games.
From their childhood encounters to their adulthood as successful game developers, the book delves into themes of identity, creativity, disability, and the redemptive possibilities in play.
It is a coming-of-age story that examines the multifaceted nature of human relationships and the need to connect, love, and be loved.
The novel is praised for its mature and nuanced portrayal of characters and its ability to engage readers even without prior knowledge of the video game industry.
#3577
• Mentioned in 11 episodes
Searching for Bobby Fischer
Blackstone Audiobooks Inc.
This memoir recounts the journey of Fred Waitzkin and his son Joshua into the world of chess.
Inspired by the historic Fischer-Spassky championship match, Waitzkin's son Josh begins playing chess at six and quickly becomes a prodigy.
The book explores their travels, tournaments, and the impact on their relationship, as well as the broader world of chess and the enigmatic figure of Bobby Fischer.
It delves into the pressures and challenges faced by Josh and the ethical dilemmas of parenting a prodigy, making it a story about fathers, sons, and the complexities of ambition and love.
#316
• Mentioned in 68 episodes
Nonviolent Communication
A Language of Life
Marshall B. Rosenberg
Nonviolent Communication (NVC) is a framework created by Marshall Rosenberg that aims to enhance communication by promoting compassion and empathy.
The book outlines a four-step process for effective communication: observing what is happening without judgment, identifying and expressing feelings, recognizing and articulating needs, and making clear requests.
Rosenberg emphasizes the importance of separating observations from evaluations to avoid defensiveness and promote genuine human connections.
The book includes practical exercises, role-plays, and real-life examples to illustrate how NVC can be applied in various relationships and situations, including personal, professional, and conflict resolution contexts.
It also discusses how NVC can help in developing self-compassion and resolving conflicts by focusing on the underlying needs rather than the actions that trigger emotions.
#7491
• Mentioned in 5 episodes
The Mind of a Mnemonist
A Little Book About a Vast Memory
A.R. Luria
#368
• Mentioned in 61 episodes
Awareness
a de Mello spirituality conference in his own words
Anthony de Mello
In 'Awareness', Anthony de Mello combines Christian spirituality, Buddhist parables, Hindu breathing exercises, and psychological insight to challenge readers to wake up from the go-go-go world of illusion.
The book, composed of short chapters and lectures, encourages readers to become aware of their thoughts, actions, and motivations.
De Mello argues that true happiness and freedom come from dropping illusions and living in the present, free from the constructs of culture, conditioning, and fear.
He emphasizes the need to observe oneself, understand negative feelings, and practice detachment to achieve a more authentic and fulfilling life.
Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!
This episode is brought to you by:
Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/Tim
David Protein Bars with 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/Tim (Buy 4 cartons, get the 5th free.)
Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $400 off your very own Pod 5 Ultra)
Coyote the card game, which I co-created with Exploding Kittens: https://coyotegame.com
Timestamps:
- [00:00:00] Start.
- [00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
- [00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
- [00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
- [00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
- [00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
- [00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
- [00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
- [00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
- [00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
- [00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
- [01:02:05] Holiday gift ideas and recommended reading.
- [01:17:41] The Way App and meditation with Zen master Henry Shukman.
- [01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
- [01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
- [01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
- [01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
- [01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
- [01:47:58] Parting thoughts and happy holidays.
*
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