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@jlandsborough
Ep. 250: In Defense of Thinking
Arnold Bennett's Advice on Concentration and Mind Control
AI Key Takeaways
- Concentration is essential for a fulfilling life
- Arnold Bennett's book, How to Live on 24 Hours a Day, provided early advice on self-improvement
- Bennett emphasized the importance of focusing the mind on a subject throughout the day
- He compared the need for concentration to the daily commute of suburban knowledge workers
- He encouraged persistence in training the mind to concentrate
- Bennett acknowledged that the mind is capable of concentration based on past experiences
@jlandsborough
Ep. 249: The Good Enough Job (w/ Simone Stolzoff)
The Importance of Diversifying Your Identity
AI Key Takeaways
- The book advocates for diversifying one's identity
- Diversifying sources of meaning and identity leads to resilience in the face of change
- Having multiple interests and hobbies can lead to more creative problem solving
- In the knowledge economy, it is important to have space in your day for synthesis of ideas
@jlandsborough
#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.
The End of the HDL Hypothesis and the Role of Mendelian Randomizations in ASCVD
AI Key Takeaways
- A drug was pushed into phase three without fully understanding its side effects in phase two.
- The drug Dalsetra raised HDL cholesterol but had no effect on LDL or non HDL cholesterol, and did not reduce heart attack or stroke.
- Mendelian randomizations have shown that high HDL cholesterol is not causally linked to ASCVD.
- The belief that high HDL cholesterol can protect against coronary artery disease in the presence of high LDL cholesterol is unsupported by evidence.
@jlandsborough
Ep. 248: Decoding Overload
Reducing Overhead with a Communication Plan
AI Key Takeaways
- Taming the way coordination collaboration occurs can help with overload issues
- Writing a communication plan for a company or team can reduce the footprint of necessary coordination and collaboration
- Email can be used for certain purposes, such as announcing information that does not require a reply and urgent questions that can be answered with a single reply
@jlandsborough
Ep. 248: Decoding Overload
How Microsoft uses cloud data to track knowledge worker tasks of email and meetings
AI Key Takeaways
- Microsoft can analyze cloud-hosted software usage to understand how knowledge workers spend their time
- Most active Microsoft app users were studied to determine time usage patterns
- Average Microsoft software user spends 8.8 hours per week on emails and 7.5 hours per week in digital meetings
@jlandsborough
Hunger, weight loss and obesity | Stephan Guyenet, PhD
Food properties that help you feel fuller on fewer calories
AI Key Takeaways
- The satiety of a food is strongly correlated with its calorie density, volume, fiber content, protein content, and palatability.
- Blood glucose response does not correlate with satiety, while insulin response is inversely correlated.
- Physical and chemical properties of food are the main drivers of satiety.
- Selecting foods with higher satiety value per calorie can help control calorie intake without feeling hungry.
- Lower calorie density and minimally refined and processed foods are more consistent with ancestral diets.
@jlandsborough
Hunger, weight loss and obesity | Stephan Guyenet, PhD
The Role of Adipose Tissue in Energy Storage, Fat Threshold, and Energy Poisoning
AI Key Takeaways
- Adipose tissue is designed to efficiently store energy and protect other tissues.
- Exceeding your personal fat threshold leads to impaired fat storage and clearance.
- Fat deposition in organs and tissues is a sign of excessive energy circulation.
- Insulin resistance occurs when tissues refuse to take up more energy.
- Insulin resistance contributes to cardiovascular disease and diabetes risk.
- Energy poisoning degrades beta cells in the pancreas.
@jlandsborough
Hunger, weight loss and obesity | Stephan Guyenet, PhD
Obesity rates in middle-aged white men in the United States vs 1800s
AI Key Takeaways
- Data on obesity rates in the United States go back to the late 1800s, showing a significant increase over time
- In the late 1800s, only about 1 in 17 middle-aged white men had obesity, compared to around 1 in 2 today
- The pace of obesity increase accelerated between the mid-1970s and mid-1980s, leading to what is known as the obesity epidemic
- The obesity rates have been continuously rising since the epidemic started over 40 years ago
- As of the latest CDC data, 43% of US adults have obesity
@jlandsborough
Hydration for optimal health and performance | Stacy Sims, PhD
The Myth of Coffee and Tea as Diuretics
AI Key Takeaways
- Coffee and tea are not dehydrating, contrary to popular belief.
- Drinking coffee or tea can actually contribute to fluid intake.
- Caffeine is not a diuretic, but rather a volume response.
- Drinks like alcohol and high sugar drinks are counterintuitive for hydration.
@jlandsborough
Hydration for optimal health and performance | Stacy Sims, PhD
Sugar-Free Electrolyte Tablets: Glucose helps with fluid absorption
AI Key Takeaways
- Sugar-free electrolyte tablets often contain sugar alcohols like stevia or xylitol.
- Some people avoid sugar in electrolyte tablets but still need glucose for fluid absorption.
- Having a small amount of glucose is beneficial for optimal fluid absorption during hydration.
@jlandsborough
Hydration for optimal health and performance | Stacy Sims, PhD
The origins and marketing success of Gatorade
AI Key Takeaways
- Electrolyte companies are now promoting sugar-free options while sports drinks like Gatorade are loaded with sugar.
- Carbohydrates improve hydration by activating fluid transport mechanisms in the small intestines.
- Sucrose and glucose can activate all fluid transport mechanisms to maximize fluid absorption.
- Gatorade originated from a need to hydrate athletes and evolved to focus on supplying carbohydrates for performance.
- Research supports the role of carbohydrates in performance, but not in hydration.
@jlandsborough
Hydration for optimal health and performance | Stacy Sims, PhD
The Importance of Sodium and Potassium Post-Exercise
AI Key Takeaways
- Electrolyte supplements on the market often contain sodium, potassium, and magnesium.
- Adding potassium to fluid absorption is important post-exercise.
- Potassium helps with the sodium-potassium pump in physiology.
- Sodium is critical for getting fluid from the gut into the plasma space.
- Sodium is critical for rehydrating all spaces of the body post-exercise.
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