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Hunger, weight loss and obesity | Stephan Guyenet, PhD

The Proof with Simon Hill

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The Role of Adipose Tissue in Energy Storage, Fat Threshold, and Energy Poisoning

Adipose tissue functions as a professional energy storage organ by efficiently trapping and holding onto excess energy in the form of fatty acids. However, there is a limit to the amount of fat that can be safely stored, known as the personal fat threshold. Beyond this threshold, the adipose tissue is unable to effectively trap fat, resulting in elevated levels of fatty acids in the bloodstream. This leads to the deposition of fat in other organs and tissues, such as the liver, muscle, and pancreas, which is a clear sign of energy poisoning. Excess energy circulating in the body causes physiological changes, including insulin resistance, where tissues refuse to take up glucose as they are already saturated with energy. Insulin resistance contributes to cardiovascular disease and diabetes risk. Energy poisoning also affects the beta cells in the pancreas, degrading their function and further increasing the risk of diabetes.

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