The Immunology Podcast

Guest: Dr. Theresa Alenghat is a Professor in the Immunobiology Division and the Margaret K. Hostetter Chair at Cincinnati Children’s Hospital Medical Center, University of Cincinnati. Her lab investigates mechanisms underlying the host-microbiota relationship, and how this regulation affects intestinal immunity and inflammatory bowel disease.  She discusses how butyrate affects tuft cells in the intestine. Featured Products and Resources: Submit your abstract for IMMUNOLOGY2025! Add Intestinal Organoids to Your Research with IntestiCult. The Immunology Round Up Ancient Cheese – Researchers retrieved DNA from ancient kefir cheese to study how human-microbial interactions contribute to the adaptation of domesticated lactobacilli. Mitochondrial Movement – Mitochondrial transfer augments CD8+ T cell mitochondria mass and metabolic fitness. CAR T Atlas – Scientists generated a single-cell atlas of pre-infusion CAR T cells and found that elevated type 2 functionality is associated with remission of leukemia. NAD+ Reconstitution – A unique immune evasion strategy allows viruses to rebuild molecules depleted by the host’s defense system. Image courtesy of Dr. Theresa Alenghat Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Roslyn Kemp, a Professor of Immunology at the University of Otago, dives into the fascinating world of T cells and their critical roles in fighting cancer and inflammation. She reveals how organoids can model inflammatory bowel diseases like Crohn's, enhancing our understanding of immune interactions. The conversation also touches on innovative approaches to cancer therapy, the effects of testosterone on the immune response in transgender men, and the importance of inquiry in science as a catalyst for collaboration and innovation.

Dr. Wayne Juang, a Field Application Scientist at STEMCELL Technologies, shares his journey from academia to industry while tackling practical immunology challenges. He dives into genetic factors impacting tuberculosis and explores the role of sodium chloride in enhancing T cell functionality in tumors. The discussion highlights how dietary components, like oleic acid, can affect influenza severity. Juang also emphasizes the importance of bridging scientific knowledge with industry needs and shares insights on navigating career opportunities in immunology.

Dr. Kipp Weiskopf, a Valhalla Fellow at the Whitehead Institute, delves into the crucial role of macrophages in cancer therapy. He explains how targeting the CD47/SIRPα axis can promote the destruction of cancer cells. Weiskopf also shares insights on launching spin-off companies aimed at advancing innovative cancer treatments. The conversation explores the complexity of macrophage function within tumors and the emerging therapeutic strategies designed to harness their power for better patient outcomes.

Dr. Adrian Erlebacher, a Professor at UCSF, delves into reproductive immunology, focusing on immune tolerance during pregnancy. He explains how the maternal-fetal interface affects pregnancy outcomes and touches on challenges translating animal studies to human pregnancy. The importance of glycans in immune modulation is emphasized, alongside discussions about the complexity of immune responses and factors influencing preterm labor. This fascinating conversation highlights the intersection of maternal health and immunology.

Dr. Jeffrey Rathmell, the Cornelius Vanderbilt Professor of Immunobiology, dives into T cell metabolism and its critical role in cancer. He discusses how T cells utilize fatty acids as fuel and the intriguing 'obesity paradox' in cancer immunotherapy. Rathmell also reflects on the joys of being a scientist and professor, emphasizing the importance of mentorship and collaboration in research. Explore the metabolic shifts in T cells and their implications for therapy as he shares insights into the evolving landscape of immunology.

Dr. Shana Kelley, President of the Chan Zuckerberg Biohub Chicago and professor at Northwestern University, discusses her pioneering work on reagentless biosensors that track molecular interactions without additional reagents. She explores the innovative application of DNA-based systems in detecting binding events, enhancing immunology research. Kelley also shares insights into balancing her scientific career with family life, along with humorous anecdotes about navigating teenage adventures and the mysteries of pet behavior.

Dr. Susan Kaech, a leading immunologist at the Salk Institute, discusses her groundbreaking research on memory T cells and T cell exhaustion, shedding light on why they sometimes fail to provide lasting immunity. She shares insights into neuroimmunology, revealing how stress impacts T cell behavior and immune function. Kaech also reflects on her unique journey from genetics to immunology, emphasizing the importance of understanding memory in infections and cancer. A fascinating exploration of the immune system's complexity!

Dr. Priya Devarajan, an Assistant Professor at Stony Brook University, specializes in immune memory and respiratory immunology. She discusses how aging impacts the immune system and promotes strategies for enhancing immune responses in the lungs and nose. The conversation also dives into improving influenza vaccine efficacy and the potential of nasal vaccines for combating respiratory infections. With insights into academic career paths, she emphasizes individual journeys in science and the importance of representation, especially for women in academia.

Dr. Erika Moore, an Assistant Professor at the University of Maryland, delves into the fascinating world of engineered biomaterials for regenerative medicine. She discusses rejuvenating macrophages and innovative approaches to treat lupus. The conversation also highlights the significance of using appropriate cells in research, and Dr. Moore emphasizes the need for financial literacy to enhance access to scientific careers. Listeners gain insights into the intersection of engineering, immunology, and the importance of inclusivity in the scientific community.