The Immunology Podcast

Dr. Adrian Erlebacher, a Professor at UCSF, delves into reproductive immunology, focusing on immune tolerance during pregnancy. He explains how the maternal-fetal interface affects pregnancy outcomes and touches on challenges translating animal studies to human pregnancy. The importance of glycans in immune modulation is emphasized, alongside discussions about the complexity of immune responses and factors influencing preterm labor. This fascinating conversation highlights the intersection of maternal health and immunology.

Dr. Jeffrey Rathmell, the Cornelius Vanderbilt Professor of Immunobiology, dives into T cell metabolism and its critical role in cancer. He discusses how T cells utilize fatty acids as fuel and the intriguing 'obesity paradox' in cancer immunotherapy. Rathmell also reflects on the joys of being a scientist and professor, emphasizing the importance of mentorship and collaboration in research. Explore the metabolic shifts in T cells and their implications for therapy as he shares insights into the evolving landscape of immunology.

Dr. Shana Kelley, President of the Chan Zuckerberg Biohub Chicago and professor at Northwestern University, discusses her pioneering work on reagentless biosensors that track molecular interactions without additional reagents. She explores the innovative application of DNA-based systems in detecting binding events, enhancing immunology research. Kelley also shares insights into balancing her scientific career with family life, along with humorous anecdotes about navigating teenage adventures and the mysteries of pet behavior.

Dr. Susan Kaech, a leading immunologist at the Salk Institute, discusses her groundbreaking research on memory T cells and T cell exhaustion, shedding light on why they sometimes fail to provide lasting immunity. She shares insights into neuroimmunology, revealing how stress impacts T cell behavior and immune function. Kaech also reflects on her unique journey from genetics to immunology, emphasizing the importance of understanding memory in infections and cancer. A fascinating exploration of the immune system's complexity!

Dr. Priya Devarajan, an Assistant Professor at Stony Brook University, specializes in immune memory and respiratory immunology. She discusses how aging impacts the immune system and promotes strategies for enhancing immune responses in the lungs and nose. The conversation also dives into improving influenza vaccine efficacy and the potential of nasal vaccines for combating respiratory infections. With insights into academic career paths, she emphasizes individual journeys in science and the importance of representation, especially for women in academia.

Dr. Erika Moore, an Assistant Professor at the University of Maryland, delves into the fascinating world of engineered biomaterials for regenerative medicine. She discusses rejuvenating macrophages and innovative approaches to treat lupus. The conversation also highlights the significance of using appropriate cells in research, and Dr. Moore emphasizes the need for financial literacy to enhance access to scientific careers. Listeners gain insights into the intersection of engineering, immunology, and the importance of inclusivity in the scientific community.

Dr. Kellen Cavagnero, a Postdoctoral Fellow at UC San Diego, dives into the surprising role of fibroblasts in inflammatory conditions and their defense against staph infections. He sheds light on antimicrobial resistance and how these immune-acting fibroblasts can recruit neutrophils during inflammation. The conversation also touches on his podcast, Inflammatory Content, revealing his passion for science communication. Kellen emphasizes the need to rethink fibroblasts’ roles in immune responses, challenging long-held assumptions in immunology.

In May 2024, researchers gathered in Chicago to discuss groundbreaking immunology innovations. Key topics included advancements in vaccine research, the gut-brain axis in cancer therapy, and the dynamics of immune cells. Attendees shared reflections on networking opportunities and memorable presentations, emphasizing the significance of collaborations in the scientific community. Meanwhile, personal insights included the excitement of discussing CAR T cells and the exploration of the city's vibrant culture, creating a unique blend of science and adventure.

In this insightful discussion, Dr. Jo Viney, CEO of Seismic Therapeutic, and Dr. Ryan Peckner, Director of Machine Learning, delve into the exciting intersection of artificial intelligence and immunology. They explore the transformative role AI plays in drug discovery and protein engineering, unveiling its potential to innovate antibody development and enhance therapeutic efficacy. The duo also addresses the challenges in integrating AI into clinical trials and underscores the importance of human expertise alongside AI for reliable scientific advancements.

Dr. Frances Lund, a renowned immunologist known for her research on T cell dysfunction and B cell differentiation, shares her latest findings. They delve into the impacts of lactate metabolism on exhausted T cells and the fascinating role of mitochondria in immune dynamics. The discussion highlights novel pathways of B cell responses that operate independently of T cells, offering insights into autoimmune diseases and vaccine development. They wrap up the conversation with reflections from the IMMUNOLOGY2024 conference.