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The Immunology Podcast

Ep. 99: “Inflammation and Innate Immunity” Featuring Dr. Luke O’Neill

Feb 25, 2025
Dr. Luke O’Neill, a biochemistry professor at Trinity College Dublin, dives deep into the world of inflammation and innate immunity. He explores how macrophages influence inflammatory responses and their potential role in treating nerve damage. The conversation includes exciting findings about T-cells in asthma and novel anti-inflammatory therapies being developed. O'Neill also discusses the burgeoning field of immunometabolism, where metabolism intersects with immune functionality, shedding light on future treatments for various diseases.
01:20:51

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • The podcast highlights the essential role of toll-like receptors in initiating immune responses and bridging innate and adaptive immunity.
  • Research reveals that Granzyme K, produced by CD8 T cells, exacerbates airway inflammatory diseases, suggesting interventions could improve lung function.

Deep dives

Innate Immunity and Toll-like Receptors

The discussion focuses on the role of toll-like receptors (TLRs) in innate immunity, particularly their function in recognizing pathogens and activating immune responses. TLRs are essential for identifying diverse microbial patterns and initiating inflammation, bridging the innate and adaptive immune systems. This includes the processes of signal transduction that dictate how cells respond to immune challenges. Future research is anticipated to uncover more complex interactions between TLRs and various immune mediators.

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