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Ep. 99: “Inflammation and Innate Immunity” Featuring Dr. Luke O’Neill

The Immunology Podcast

CHAPTER

T-Cells, Granzyme K, and Macrophage Dynamics in Disease

This chapter examines the intricate role of T-cells and Granzyme K in patients with nasal polyps and asthma, highlighting their potential non-cytotoxic functions and implications in immune responses. It also explores the modulation of macrophages in graft-versus-host disease and the protective effects of IL-34 during transplants, emphasizing the evolving understanding of these immune cells. Lastly, the chapter addresses the impact of high-fat diets on peripheral neuropathy, connecting metabolic changes to nerve function disruption and macrophage involvement in repair processes.

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