The Immunology Podcast

Guest: Dr. Arthur Mortha is an Associate Professor at the University of Toronto. His research focuses on innate lymphoid cells and their interactions with microbes. He talks about ILCs and how the gut microbiome can affect respiratory disease. (37:44) Featured Products and Resources: Register now for IUIS 2025! Enter to win a personalized lab coat! The Immunology Round Up Serotonin and Antitumor Immunity – Serotonin transporter acts as an immune checkpoint restricting CD8 T cell antitumor immunity. (3:35) T Cells in the Brain – CD4 T cells reside in the brain at steady state and are concentrated in the subfornical organ. (8:40) Bat Antiviral Immunity – A new organoid platform reveals key features of bat epithelial antiviral immunity that may inform therapeutic strategies. (22:30)) Acetylcholine in the Thymus – Cholinergic signaling regulates immune cell development through thymic negative selection. (27:00) Image courtesy of Dr. Arthur Mortha Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2025, we attended IMMUNOLOGY2025, the annual meeting of the American Association of Immunologists, in Honolulu. We chat with delegates about their research and impressions of the meeting. They discuss their reasons for attending, the most memorable research, and their experiences in Hawaiʻi. Featured Products and Resources: IUIS 2025 is taking place August 17-22 in Vienna! Prepare for your next conference. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

This special episode was recorded in front of a live audience at IMMUNOLOGY2025 in Honolulu. In this conversation, hosted by Dr. Nicole Quinn, Brenda and Jason share what they’ve learned from recording over 100 episodes of the Immunology Podcast. They talk about how the field has evolved during the past four years, the importance of making science and scientists accessible, and predictions for emerging areas of research. Featured Products and Resources: Register now for IUIS 2025! Enter to win a custom lab coat, personalized with your name! Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2025, we attended IMMUNOLOGY2025, the annual meeting of the American Association of Immunologists in Honolulu, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on lymphatic immunophysiology and how opioids drive immunosuppression in cancer. Featured Products and Resources: Download a free conference toolkit! Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2025, we attended IMMUNOLOGY2025, the annual meeting of the American Association of Immunologists in Honolulu, where we recorded daily episodes highlighting key developments from the previous 24 hours. This is the fourth of five special episodes from the meeting. In this episode, Brenda and Jason discuss how macrophages contribute to lung tissue repair and influence hormone activity, as well as the mechanisms linking MHC-II abnormalities to autoimmune disease pathogenesis. Featured Products and Resources: Register: On-Demand Human Immune Cell Isolation Course Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2025, we attended IMMUNOLOGY2025, the annual meeting of the American Association of Immunologists in Honolulu, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting. Brenda and Jason discuss highlights from sessions on mucosal immunology and the role of T cells in lactogenesis. They also talk about γδ CAR T cells and veterinary immunology — from sharks to elephants. Featured Products and Resources: Free mouse immune cell wallchart Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2025, we attended IMMUNOLOGY2025, the annual meeting of the American Association of Immunologists in Honolulu, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Brenda and Jason discuss highlights from sessions on tumor-infiltrating lymphocyte and T-cell receptor therapies, unconventional functions of Tregs, and advances in single-cell RNA sequencing. Featured Products and Resources: Register: On-Demand Human T Cell Expansion Course Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2025, we attended IMMUNOLOGY2025, the annual meeting of the American Association of Immunologists in Honolulu, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting. Brenda and Jason discuss highlights from talks including immune responses to bacterial infections, p53 reactivation for cancer therapy, and the mechanisms that lead to celiac disease. Featured Products and Resources: Stay up-to-date with the latest in immune regulation news. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Henrique Veiga-Fernandes is a Full Investigator and Group Leader at the Champalimaud Foundation. He talks about interactions between the nervous and immune systems and how ILC2s regulate blood glucose levels. (43:00) Featured Products and Resources: Register now for IMMUNOLOGY2025, taking place May 3-7 in Honolulu, Hawaii. IUIS 2025 is taking place August 17-22 in Vienna, Austria. The Immunology Science Round Up Acetylcholine Receptor in Autoimmunity – Researchers used cryoelectron microscopy to determine the high-resolution structures of the human adult AChR in different functional states. (5:20) Skin Damage and Immune Responses – Acute and chronic inflammation in the skin of mice can initiate humoral immune responses to bystander antigens in the gut. (12:35) Gut Microbes and Th17 Cells – A. faecalis outer membrane vesicles promote intestinal Th17 cell generation. (23:15) Sex Differences in Pain Sensing – Depleting Tregs cells localized to the meninges of the central nervous system increased the responses of female, but not male, mice to mechanical pain stimuli. (32:00) Image courtesy of Dr. Henrique Veiga-Fernandes Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Monika Wolkers is a Group Leader at the Sanquin Blood Supply Foundation and an Associate Professor at the University of Amsterdam. Her research focuses on RNA-binding proteins and how they affect T cell function. She talks about  γδ T cells in immunotherapy, targeting pediatric tumors, and how a sabbatical led her to study RNA-binding proteins. (46:50) Featured Products and Resources: Register now for IMMUNOLOGY2025, taking place May 3-7 in Honolulu, Hawaii. IUIS 2025 is taking place August 17-22 in Vienna, Austria. The Immunology Science Round Up Macrophages in Liver Regeneration – Glutamate supports liver regeneration by stabilizing HIF1α in bone-marrow-derived macrophages. (4:33) A High-Salt Diet and Depression – A high-salt diet induces depression-like behavior symptoms in mice. (15:30) A New Broad-Spectrum Antibiotic – The lasso peptide antibiotic lariocidin inhibits the bacterial ribosome. (29:10) Boosting Antigen Cross-Presentation with STING – Researchers developed a new vaccine technology that stimulates CD8+ T cells and shows promise in mouse models of cancer and SARS-CoV-2 infection. (36:45) Image courtesy of Dr. Monika Wolkers Subscribe to our newsletter! Never miss updates about new episodes. Subscribe