Dr. Erica Saphire, President and CEO of the La Jolla Institute, specializes in viral immunity and pathogenesis. She shares insights on the groundbreaking capabilities of cryo-electron microscopy, revealing how it can illuminate viral fusion processes like those of the measles virus. Saphire also discusses her leadership role and highlights the importance of research in combating viral diseases. The conversation spotlights the evolution of antibody responses and the innovative use of AI in structural biology to tackle complex viral challenges.

Dr. Nicole Quinn, Director of Brand and Scientific Communications at STEMCELL Technologies and co-host of Lab Coats & Life Podcast, discusses vital elements of mentorship in science. She shares insights from her journey into podcasting, emphasizing the significance of soft skills and trends in the scientific community. Their conversation also highlights the importance of professional visibility and diverse career paths for scientists. Listeners can look forward to the second season, focusing on fostering mentorship and staying informed in the ever-evolving scientific landscape.

Dr. Gail Bishop, a Professor at the University of Iowa and Editor-in-Chief of The Journal of Immunology, dives into the fascinating world of lymphocyte signaling. She discusses the intricacies of TRAF signaling and the NFκB pathway's effects on B and T lymphocytes, shedding light on their roles in immunity. Additionally, the podcast touches on innovative T-cell receptor engineering and the surprising functions of macrophages in muscle interactions. Gail's insights into her editorial role reveal the evolving landscape of scientific publishing.

Dr. Lili Yang, a renowned professor at UCLA specializing in immunotherapy for cancer, dives into her innovative research on engineering off-the-shelf treatments. She discusses the exciting potential of CAR-NKT cells derived from stem cells, highlighting advancements in accessibility to therapies. Lili also explores the surprising link between serotonin, SSRIs, and their impact on cancer treatment efficacy. Her insights challenge traditional views, merging the realms of mental health and immunology in groundbreaking ways.

Dr. Rahul Roychoudhuri, a Professor of Cancer Immunology at the University of Cambridge, shares insights on groundbreaking research in cancer treatment. He discusses enhancing cancer cell targeting through innovative cell therapies and the role of immunomodulators like aspirin in preventing metastasis. The conversation also delves into the complexities of immune regulation in cardiac health and how recent discoveries in synthetic immunology could transform patient outcomes. This blend of cutting-edge research and practical applications makes for an intriguing listen!

Dr. Pascal Meier, a Professor at the Institute of Cancer Research in London, dives into the intricate connections between cell death and immunity. He discusses the significance of different cell death types, such as necroptosis and pyroptosis, in shaping immune responses, especially in cancer. The conversation also highlights the revolutionary role of engineered bacteria in enhancing anti-tumor immunity and the implications of chronic inflammation in health. Lastly, Meier shares insights on pursuing personal passions in a scientific career, blending professional and personal growth.

Dr. Marcelo Hill, head of the Laboratory of Immunoregulation and Inflammation at the Institut Pasteur de Montevideo, discusses enhancing immunotherapy for cancer through inflammasome activation. He emphasizes collaboration with industry to advance research. Joining him, Marion Brunck and María Julia Lamberti share insights on the Latin American immunology community, addressing challenges and opportunities for early-career researchers. They highlight the importance of the upcoming conference aimed at fostering collaboration and amplifying research visibility in the region.

Join Dr. JoAnne Flynn, a renowned tuberculosis researcher, and Dr. Stephen Hedrick, an expert in T cell receptors, as they dive into the 'Immunology Explained' campaign. They discuss how it aims to demystify immunology for the public and educate legislators about the importance of immunology research. The duo tackles complex topics like vaccine advocacy, the significance of natural killer cells in fighting RSV in children, and the challenge of addressing vaccine skepticism while promoting informed public health decisions.

Guest: Dr. Theresa Alenghat is a Professor in the Immunobiology Division and the Margaret K. Hostetter Chair at Cincinnati Children’s Hospital Medical Center, University of Cincinnati. Her lab investigates mechanisms underlying the host-microbiota relationship, and how this regulation affects intestinal immunity and inflammatory bowel disease.  She discusses how butyrate affects tuft cells in the intestine. Featured Products and Resources: Submit your abstract for IMMUNOLOGY2025! Add Intestinal Organoids to Your Research with IntestiCult. The Immunology Round Up Ancient Cheese – Researchers retrieved DNA from ancient kefir cheese to study how human-microbial interactions contribute to the adaptation of domesticated lactobacilli. Mitochondrial Movement – Mitochondrial transfer augments CD8+ T cell mitochondria mass and metabolic fitness. CAR T Atlas – Scientists generated a single-cell atlas of pre-infusion CAR T cells and found that elevated type 2 functionality is associated with remission of leukemia. NAD+ Reconstitution – A unique immune evasion strategy allows viruses to rebuild molecules depleted by the host’s defense system. Image courtesy of Dr. Theresa Alenghat Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Roslyn Kemp, a Professor of Immunology at the University of Otago, dives into the fascinating world of T cells and their critical roles in fighting cancer and inflammation. She reveals how organoids can model inflammatory bowel diseases like Crohn's, enhancing our understanding of immune interactions. The conversation also touches on innovative approaches to cancer therapy, the effects of testosterone on the immune response in transgender men, and the importance of inquiry in science as a catalyst for collaboration and innovation.