The Immunology Podcast

Ep. 116: “Allelic Variation” Featuring Dr. Robin Orozco

Oct 7, 2025
Guest
Dr. Robin Orozco
Dr. Robin Orozco, an Assistant Professor at the University of Kansas, shares insights into how allelic variants like PTPN22 influence immune responses. She explains the benefits of using mouse models to uncover the effects on autoimmunity and cancer. Orozco discusses the nuanced trade-offs between protection against infections and the increased risk of autoimmunity posed by PTPN22. She also highlights her approach to teaching and mentorship, emphasizing a human-centered methodology in scientific practice.
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INSIGHT

In Vivo Screens Find Different CAR T Targets

  • In vivo CRISPR screens of CAR T cells reveal targets that differ from in vitro hits.
  • RhoG and FAS knockouts enhanced CAR T proliferation and persistence in mouse tumor models.
INSIGHT

Cell-Cycle Genes Promote CAR T Persistence

  • Another in vivo CAR T screen (myeloma) identified CDKN1B as a top hit for persistence.
  • Different screens highlight cell-cycle regulators as promising targets but raise safety questions.
INSIGHT

Allelic Variants Reveal Signaling Nuance

  • Studying human allelic variants in mice reveals nuanced immune regulation that knockouts miss.
  • PTPN22 variants alter antigen-specific T cell function differently than full gene deletions.
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