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Ep. 116: “Allelic Variation” Featuring Dr. Robin Orozco

The Immunology Podcast

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Biochemistry and Functional Effects of the PTPN22 Variant

Orozco details the R→W PTPN22 P1-domain change, its interaction partners (CSK, TRAF3), and how it modulates TCR signaling, migration, and autoimmunity risk.

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