The Immunology Podcast

Ep. 119: “Systemic Lupus Erythematosus” Featuring Dr. George Robinson

Nov 18, 2025
Guest
George Robinson
Dr. George Robinson, a Principal Research Fellow at University College London, dives into juvenile-onset systemic lupus erythematosus and its complexities. He discusses current diagnostic tests and innovative treatments, including CAR T-cell therapy. The conversation explores sex differences in autoimmunity, considering how hormones and genetics impact the disease. Robinson also highlights his lab's work on longitudinal biobanking and the potential for lifestyle changes to influence remission. His insights into the ongoing research landscape bring a hopeful perspective to lupus treatment.
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INSIGHT

Lupus Is A Heterogeneous, Overlapping Disease

  • Systemic lupus erythematosus (SLE) is highly heterogeneous across patients and often overlaps other autoimmune diseases.
  • That heterogeneity makes diagnosis and research difficult and requires multiomic and longitudinal approaches.
INSIGHT

Autoantibodies Drive Tissue Damage

  • Anti-dsDNA and anti-nuclear antibodies are primary blood markers used in SLE diagnosis.
  • Immune complexes with nucleic acids deposit in tissues, driving organ-specific manifestations such as lupus nephritis.
INSIGHT

Studying Juvenile-Onset Lupus Gives Clinical Leverage

  • George Robinson focuses on juvenile-onset SLE, which is more aggressive and has worse outcomes than adult-onset disease.
  • He leverages a clinical biobank and close clinician-scientist collaboration for translational, longitudinal studies.
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