Critical Care Reviews Podcast

Rob Mac Sweeney discusses the ACIOS study with Tim Baker, the study lead. ACIOS is a point prevalence study describing the burden of critical illness in Africa. It was published in the Lancet in March, 2025.

Lars Wiuff Andersen, a leading expert in pre-hospital critical care, and Mikael Fink Valentine, a researcher in cardiac arrest, delve into the findings of the groundbreaking IVIO trial. They compare intraosseous and intravenous access methods during out-of-hospital cardiac arrests. The discussion reveals similar efficacy between the two techniques, emphasizing the importance of skilled emergency teams. Insights into medication access routes and the implications of trial outcomes for future emergency practices are particularly fascinating.

Rob Mac Sweeney discusses the PARAMEDIC 3 trial with it's investigators Keith Couple and Ranjit Lall from the University of Warwick, England. PARAMEDIC 3 compared intravenous with intraosseous vascular access in adult patients suffering cardiac arrest and requiring drug administration during ongoing resuscitation. It was presented at the European Resuscitation Council meeting in Athens on October 31st and simultaneously published in the New England Journal of Medicine.

Rob Mac Sweeney chats with Jessica Spence about the B-FREE trial, investigating benzodiazepine-free anaesthesia for the prevention of delirium in cardiac surgery

Experts from around the globe discuss the concept and challenges of platform trials in clinical research. They explore the efficiencies, funding issues, and statistical considerations of transitioning to big team science. The role of patient groups in trial designs and the challenges of educating institutional review boards and securing funding are also highlighted.

Experts from diverse backgrounds discuss causality at the Critical Care Reviews Meeting 2023. They explore challenges in establishing causality through trials and the importance of maintaining integrity in research practices. The panel delves into the complexities of determining causality in clinical trials, emphasizing personalized treatment approaches and the future of critical care research.

Dr. Lisa Higgins presents long-term outcomes of REMAP-CAP trial at Critical Care Reviews Meeting 2023. Prof. Christopher Seymour explores 180-day outcomes for pandemic patients. Analysis includes treatments like antivirals, corticosteroids, and anticoagulants. Challenges in post-ICU follow-up and successes of platforms like Remap Cap discussed.

Explore the AID-ICU trial investigating the use of Haloperidol for delirium in the ICU, with insights from experts discussing impact, findings, and limitations. Reflect on outcome assessment in clinical trials during a pandemic, patient experiences, and the effectiveness of Haloperidol in treating uncontrollable delirium.

Prof Flavia Machado (Sao Paulo) delivers the John Hinds Lecture at the Critical Care Reviews Meeting 2023, describing the story of BRICNET, the Brazilian Critical Care Trials Group. The session commences with Dr Chris Nutt remembering our friend, Dr John Hinds.

You're listening to the audio version of the PROCOAG trial presentation from the Critical Care Reviews Meeting 2023. The PROCOAG trial investigated the efficacy and safety of early administration of 4-factor prothrombin complex concentrate in trauma patients at risk of massive transfusion. The trial is presented by Pierre Bouzat from Grenoble. Susan Rowell from Chicago, delivers the editorial. The session is chaired by Chris Seymour (Pittsburgh). PROCOAG was published in JAMA in March 2023.